Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle

Jing Zhou, Gayatri Shrikhande, Jing Xu, Renée M. Mckay, Dennis K. Burns, Jane E. Johnson, Luis F. Parada

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Subependymal nodules (SENs) and subependymal giant cell astrocytomas (SEGAs) are common brain lesions found in patients with tuberous sclerosis complex (TSC). These brain lesions present a mixed glioneuronal phenotype and have been hypothesized to originate from neural stem cells. However, this hypothesis has not been tested empirically. Here, we report that loss of Tsc1 in mouse subventricular zone (SVZ) neural stem/progenitor cells (NSPCs) results in formation of SEN- and SEGA-like structural abnormalities in the lateral ventricle, the consequence of abnormal migration of NSPCs following Tsc1 loss.

Original languageEnglish (US)
Pages (from-to)1595-1600
Number of pages6
JournalGenes and Development
Volume25
Issue number15
DOIs
StatePublished - Aug 1 2011

Keywords

  • Lateral ventricle (LV)
  • Neural stem/progenitor cells
  • Subependymal giant cell astrocytomas (SEGAs)
  • Subependymal nodules (SENs)
  • Tuberous sclerosis complex (TSC)

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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