Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection

Hao Chen, Robert Klein, Stacy Arnold, Yiying Wang, Setsuko Chambers, Wenxin Zheng

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Currently, it is widely accepted that the vast majority of ovarian high-grade serous carcinoma (HGSC) originate from the fallopian tube. However, due to the lack of markers or tools for the ovarian cancer identification, the early detection of HGSC remains challenging. Direct sampling of the fallopian tube can enhance sensitivity for detection of neoplastic cells when the tumor is not grossly visible. We developed a procedure to collect fallopian tube cells directly from freshly received surgical specimens, which has shown excellent correlation with histological findings. This approach lays a foundation for the future utility of minimally invasive laparoscopic screening in high-risk patient populations.

Original languageEnglish (US)
JournalJournal of visualized experiments : JoVE
Issue number125
DOIs
StatePublished - Jul 25 2017

ASJC Scopus subject areas

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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