Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Mohammad Ezzati, Ovrang Djahanbakhch, Sara Arian, Bruce R. Carr

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

With the advent of assisted reproductive technology in the past three decades, the clinical importance of fallopian tubes has been relatively overlooked. However, successful spontaneous conception requires normal function of the tube to provide not only a conduit for the gametes to convene and embryo to reach the uterine cavity, but also a physiologically optimized environment for fertilization and early embryonic development. In this review, after a brief description of normal human tubal anatomy and histology, we will discuss tubal transport and its principal effectors, including ciliary motion, muscular contractility and tubal fluid. Furthermore, we will discuss the ciliary ultrastructure and regulation of ciliary beat frequency by ovarian steroids, follicular fluid, angiotensin system, autonomic nervous system and other factors such as adrenomedullin and prostaglandins. In the last section, we describe the adverse impact of various pathological conditions, such as endometriosis, infection and smoking on tubal function and ciliary motility.

Original languageEnglish (US)
Pages (from-to)1337-1347
Number of pages11
JournalJournal of Assisted Reproduction and Genetics
Volume31
Issue number10
DOIs
StatePublished - Sep 23 2014

Fingerprint

Adrenomedullin
Follicular Fluid
Assisted Reproductive Techniques
Fallopian Tubes
Autonomic Nervous System
Angiotensins
Endometriosis
Fertilization
Germ Cells
Prostaglandins
Embryonic Development
Anatomy
Histology
Embryonic Structures
Smoking
Steroids
Infection

Keywords

  • Cilia
  • Ciliary beat frequency
  • Fallopian tube
  • Tubal fluid
  • Tubal transport

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology
  • Genetics
  • Genetics(clinical)

Cite this

Tubal transport of gametes and embryos : a review of physiology and pathophysiology. / Ezzati, Mohammad; Djahanbakhch, Ovrang; Arian, Sara; Carr, Bruce R.

In: Journal of Assisted Reproduction and Genetics, Vol. 31, No. 10, 23.09.2014, p. 1337-1347.

Research output: Contribution to journalArticle

Ezzati, Mohammad ; Djahanbakhch, Ovrang ; Arian, Sara ; Carr, Bruce R. / Tubal transport of gametes and embryos : a review of physiology and pathophysiology. In: Journal of Assisted Reproduction and Genetics. 2014 ; Vol. 31, No. 10. pp. 1337-1347.
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