Tubulogenesis during blood vessel formation

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The ability to form and maintain a functional system of contiguous hollow tubes is a critical feature of vascular endothelial cells (ECs). Lumen formation, or tubulogenesis, occurs in blood vessels during both vasculogenesis and angiogenesis in the embryo. Formation of vascular lumens takes place prior to the establishment of blood flow and to vascular remodeling which results in a characteristic hierarchical vessel organization. While epithelial lumen formation has received intense attention in past decades, more recent work has only just begun to elucidate the mechanisms controlling the initiation and morphogenesis of endothelial lumens. Studies using in vitro and in vivo models, including zebrafish and mammals, are beginning to paint an emerging picture of how blood vessels establish their characteristic morphology and become patent. In this article, we review and discuss the molecular and cellular mechanisms driving the formation of vascular tubes, primarily in vivo, and we compare and contrast proposed models for blood vessel lumen formation.

Original languageEnglish (US)
Pages (from-to)993-1004
Number of pages12
JournalSeminars in Cell and Developmental Biology
Volume22
Issue number9
DOIs
StatePublished - Dec 2011

Fingerprint

Blood Vessels
Paint
Zebrafish
Morphogenesis
Mammals
Embryonic Structures
Endothelial Cells

Keywords

  • Adhesion
  • Angiogenesis
  • Arhgap29
  • Blood vessel
  • Cell polarity
  • Cord hollowing
  • Endothelial cell
  • Lumen
  • NMHCIIA
  • Rasip1
  • Sialomucin
  • Vacuole
  • Vasculogenesis

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Tubulogenesis during blood vessel formation. / Xu, Ke; Cleaver, Ondine.

In: Seminars in Cell and Developmental Biology, Vol. 22, No. 9, 12.2011, p. 993-1004.

Research output: Contribution to journalArticle

@article{96c18e43dad54cf9ba99055f6bd39be6,
title = "Tubulogenesis during blood vessel formation",
abstract = "The ability to form and maintain a functional system of contiguous hollow tubes is a critical feature of vascular endothelial cells (ECs). Lumen formation, or tubulogenesis, occurs in blood vessels during both vasculogenesis and angiogenesis in the embryo. Formation of vascular lumens takes place prior to the establishment of blood flow and to vascular remodeling which results in a characteristic hierarchical vessel organization. While epithelial lumen formation has received intense attention in past decades, more recent work has only just begun to elucidate the mechanisms controlling the initiation and morphogenesis of endothelial lumens. Studies using in vitro and in vivo models, including zebrafish and mammals, are beginning to paint an emerging picture of how blood vessels establish their characteristic morphology and become patent. In this article, we review and discuss the molecular and cellular mechanisms driving the formation of vascular tubes, primarily in vivo, and we compare and contrast proposed models for blood vessel lumen formation.",
keywords = "Adhesion, Angiogenesis, Arhgap29, Blood vessel, Cell polarity, Cord hollowing, Endothelial cell, Lumen, NMHCIIA, Rasip1, Sialomucin, Vacuole, Vasculogenesis",
author = "Ke Xu and Ondine Cleaver",
year = "2011",
month = "12",
doi = "10.1016/j.semcdb.2011.05.001",
language = "English (US)",
volume = "22",
pages = "993--1004",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press Inc.",
number = "9",

}

TY - JOUR

T1 - Tubulogenesis during blood vessel formation

AU - Xu, Ke

AU - Cleaver, Ondine

PY - 2011/12

Y1 - 2011/12

N2 - The ability to form and maintain a functional system of contiguous hollow tubes is a critical feature of vascular endothelial cells (ECs). Lumen formation, or tubulogenesis, occurs in blood vessels during both vasculogenesis and angiogenesis in the embryo. Formation of vascular lumens takes place prior to the establishment of blood flow and to vascular remodeling which results in a characteristic hierarchical vessel organization. While epithelial lumen formation has received intense attention in past decades, more recent work has only just begun to elucidate the mechanisms controlling the initiation and morphogenesis of endothelial lumens. Studies using in vitro and in vivo models, including zebrafish and mammals, are beginning to paint an emerging picture of how blood vessels establish their characteristic morphology and become patent. In this article, we review and discuss the molecular and cellular mechanisms driving the formation of vascular tubes, primarily in vivo, and we compare and contrast proposed models for blood vessel lumen formation.

AB - The ability to form and maintain a functional system of contiguous hollow tubes is a critical feature of vascular endothelial cells (ECs). Lumen formation, or tubulogenesis, occurs in blood vessels during both vasculogenesis and angiogenesis in the embryo. Formation of vascular lumens takes place prior to the establishment of blood flow and to vascular remodeling which results in a characteristic hierarchical vessel organization. While epithelial lumen formation has received intense attention in past decades, more recent work has only just begun to elucidate the mechanisms controlling the initiation and morphogenesis of endothelial lumens. Studies using in vitro and in vivo models, including zebrafish and mammals, are beginning to paint an emerging picture of how blood vessels establish their characteristic morphology and become patent. In this article, we review and discuss the molecular and cellular mechanisms driving the formation of vascular tubes, primarily in vivo, and we compare and contrast proposed models for blood vessel lumen formation.

KW - Adhesion

KW - Angiogenesis

KW - Arhgap29

KW - Blood vessel

KW - Cell polarity

KW - Cord hollowing

KW - Endothelial cell

KW - Lumen

KW - NMHCIIA

KW - Rasip1

KW - Sialomucin

KW - Vacuole

KW - Vasculogenesis

UR - http://www.scopus.com/inward/record.url?scp=82755160716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82755160716&partnerID=8YFLogxK

U2 - 10.1016/j.semcdb.2011.05.001

DO - 10.1016/j.semcdb.2011.05.001

M3 - Article

C2 - 21624487

AN - SCOPUS:82755160716

VL - 22

SP - 993

EP - 1004

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

IS - 9

ER -