Tumor endothelial marker 8 promotes cancer progression and metastasis

Anette M. Høye, Sofie D. Tolstrup, Edward R. Horton, Monica Nicolau, Helen Frost, Jung H. Woo, Jeremy P. Mauldin, Arthur E. Frankel, Thomas R. Cox, Janine T. Erler

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Every year more than 8 million people suffer from cancer-related deaths worldwide [1]. Metastasis, the spread of cancer to distant sites, accounts for 90% of these deaths. A promising target for blocking tumor progression, without causing severe side effects [2], is Tumor Endothelial Marker 8 (TEM8), an integrin-like cell surface protein expressed predominantly in the tumor endothelium and in cancer cells [3, 4]. Here, we have investigated the role of TEM8 in cancer progression, angiogenesis and metastasis in invasive breast cancer, and validated the main findings and important results in colorectal cancer. We show that the loss of TEM8 in cancer cells results in inhibition of cancer progression, reduction in tumor angiogenesis and reduced metastatic burden in breast cancer mouse models. Furthermore, we show that TEM8 regulates cancer progression by affecting the expression levels of cell cycle-related genes. Taken together, our findings may have broad clinical and therapeutic potential for breast and colorectal primary tumor and metastasis treatment by targeting TEM8.

Original languageEnglish (US)
Pages (from-to)30173-30188
Number of pages16
JournalOncotarget
Volume9
Issue number53
DOIs
StatePublished - Jul 10 2018

Fingerprint

Tumor Biomarkers
Neoplasm Metastasis
Neoplasms
Colorectal Neoplasms
Breast Neoplasms
cdc Genes
Integrins
Endothelium
Membrane Proteins
Breast

Keywords

  • Angiogenesis
  • Cancer
  • Metastasis
  • Tumor endothelial marker 8

ASJC Scopus subject areas

  • Oncology

Cite this

Høye, A. M., Tolstrup, S. D., Horton, E. R., Nicolau, M., Frost, H., Woo, J. H., ... Erler, J. T. (2018). Tumor endothelial marker 8 promotes cancer progression and metastasis. Oncotarget, 9(53), 30173-30188. https://doi.org/10.18632/oncotarget.25734

Tumor endothelial marker 8 promotes cancer progression and metastasis. / Høye, Anette M.; Tolstrup, Sofie D.; Horton, Edward R.; Nicolau, Monica; Frost, Helen; Woo, Jung H.; Mauldin, Jeremy P.; Frankel, Arthur E.; Cox, Thomas R.; Erler, Janine T.

In: Oncotarget, Vol. 9, No. 53, 10.07.2018, p. 30173-30188.

Research output: Contribution to journalArticle

Høye, AM, Tolstrup, SD, Horton, ER, Nicolau, M, Frost, H, Woo, JH, Mauldin, JP, Frankel, AE, Cox, TR & Erler, JT 2018, 'Tumor endothelial marker 8 promotes cancer progression and metastasis', Oncotarget, vol. 9, no. 53, pp. 30173-30188. https://doi.org/10.18632/oncotarget.25734
Høye AM, Tolstrup SD, Horton ER, Nicolau M, Frost H, Woo JH et al. Tumor endothelial marker 8 promotes cancer progression and metastasis. Oncotarget. 2018 Jul 10;9(53):30173-30188. https://doi.org/10.18632/oncotarget.25734
Høye, Anette M. ; Tolstrup, Sofie D. ; Horton, Edward R. ; Nicolau, Monica ; Frost, Helen ; Woo, Jung H. ; Mauldin, Jeremy P. ; Frankel, Arthur E. ; Cox, Thomas R. ; Erler, Janine T. / Tumor endothelial marker 8 promotes cancer progression and metastasis. In: Oncotarget. 2018 ; Vol. 9, No. 53. pp. 30173-30188.
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