Tumor immunity meets autoimmunity: Antigen levels and dendritic cell maturation

Michael T. Spiotto, Yang Xin Fu, Hans Schreiber

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

Naïve T cells in the draining lymph node (DLN) do not immediately respond to antigenic tissues or antigenic cancers in the periphery. Rather, the conditions under which naïve T cells encounter antigen in the DLN can result in the distinct immunological states of ignorance, tolerance or immunity. Recent work suggests that these immunological states are determined by the level of antigen expressed by peripheral tissues and the maturation stage of the dendritic cell presenting the antigen. When antigens are expressed at levels that are sufficient to be cross-presented by mature dendritic cells in the DLN, naïve T cells can respond to self antigens or tumor antigens to induce a state of autoimmunity or tumor immunity, respectively. Exploiting these conditions to target unique tumor antigens will enable us to develop better cancer immunotherapies.

Original languageEnglish (US)
Pages (from-to)725-730
Number of pages6
JournalCurrent Opinion in Immunology
Volume15
Issue number6
DOIs
StatePublished - Jan 1 2003

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Autoimmunity
Dendritic Cells
Immunity
Antigens
Lymph Nodes
Neoplasm Antigens
T-Lymphocytes
Neoplasms
Autoantigens
Immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Tumor immunity meets autoimmunity : Antigen levels and dendritic cell maturation. / Spiotto, Michael T.; Fu, Yang Xin; Schreiber, Hans.

In: Current Opinion in Immunology, Vol. 15, No. 6, 01.01.2003, p. 725-730.

Research output: Contribution to journalReview article

Spiotto, Michael T. ; Fu, Yang Xin ; Schreiber, Hans. / Tumor immunity meets autoimmunity : Antigen levels and dendritic cell maturation. In: Current Opinion in Immunology. 2003 ; Vol. 15, No. 6. pp. 725-730.
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