Tumor oximetry: a comparison between near-infrared frequency-domain spectroscopy of hemoglobin saturation and 19F MRI of hexafluorobenzene

Katherine L. Worden, Yulin Song, Xin Jiang, Anca Constantinescu, Ralph P. Mason, Hanli Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Studies have shown that hypoxic tumor cells are relatively more resistant to radiotherapy, chemotherapy, and photodynamic therapy. Tumor oximetry, e.g., measurement of oxygen tension (pO 2) of tissue and/or blood oxygenation (SO 2) of the vascular bed, could be valuable for optimizing treatment plans. In this study, we employed a recently developed homodyne system to measure changes in hemoglobin saturation (SO 2) and concentration in the vascular bed of rat prostate and breast tumors. For comparison, tissue pO 2 values were measured using 19F MR EPI of hexafluorobenzene, providing a map of regional tumor oxygenation tension. Both SO 2 and pO 2 measurements were taken while the inhaled gas was alternated between 33% oxygen, 100% oxygen and carbogen (95% oxygen, 5% CO 2). The results obtained for both techniques showed significant changes in tumor oxygenation accompanying respiratory challenge, with changes in vascular SO 2 preceding tissue pO 2 change. The combined use of these two techniques provides new insight into the dynamics of tumor oxygenation by making available a method of obtaining regional information of the state of the tissue, as well as a non-invasive, real-time method for determining changes in the vascular bed.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages601-610
Number of pages10
Volume3597
StatePublished - 1999
EventProceedings of the 1999 Optical Tomography and Spectroscopy of Tissue III - San Jose, CA, USA
Duration: Jan 24 1999Jan 28 1999

Other

OtherProceedings of the 1999 Optical Tomography and Spectroscopy of Tissue III
CitySan Jose, CA, USA
Period1/24/991/28/99

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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