Abstract
Studies have shown that hypoxic tumor cells are relatively more resistant to radiotherapy, chemotherapy, and photodynamic therapy. Tumor oximetry, e.g., measurement of oxygen tension (pO 2) of tissue and/or blood oxygenation (SO 2) of the vascular bed, could be valuable for optimizing treatment plans. In this study, we employed a recently developed homodyne system to measure changes in hemoglobin saturation (SO 2) and concentration in the vascular bed of rat prostate and breast tumors. For comparison, tissue pO 2 values were measured using 19F MR EPI of hexafluorobenzene, providing a map of regional tumor oxygenation tension. Both SO 2 and pO 2 measurements were taken while the inhaled gas was alternated between 33% oxygen, 100% oxygen and carbogen (95% oxygen, 5% CO 2). The results obtained for both techniques showed significant changes in tumor oxygenation accompanying respiratory challenge, with changes in vascular SO 2 preceding tissue pO 2 change. The combined use of these two techniques provides new insight into the dynamics of tumor oxygenation by making available a method of obtaining regional information of the state of the tissue, as well as a non-invasive, real-time method for determining changes in the vascular bed.
Original language | English (US) |
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Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
Publisher | Society of Photo-Optical Instrumentation Engineers |
Pages | 601-610 |
Number of pages | 10 |
Volume | 3597 |
State | Published - 1999 |
Event | Proceedings of the 1999 Optical Tomography and Spectroscopy of Tissue III - San Jose, CA, USA Duration: Jan 24 1999 → Jan 28 1999 |
Other
Other | Proceedings of the 1999 Optical Tomography and Spectroscopy of Tissue III |
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City | San Jose, CA, USA |
Period | 1/24/99 → 1/28/99 |
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics