Tumor oximetry: Comparison of 19F MR EPI and electrodes

Ralph P. Mason, Sandeep Hunjan, Anca Constantinescu, Yulin Song, Dawen Zhao, Eric W. Hahn, Peter P. Antich, Peter Peschke

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

We recently described a novel approach to measuring regional tumor oxygen tension. This approach is based on 19F pulse burst saturation recovery NMR echo planar imaging relaxometry of hexafluorobenzene or "FREDOM" (Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping). We have now compared oxygen tension measurements using FREDOM with a traditional polarographic method (the Eppendorf Histograph) in a group of size matched Dunning prostate rat tumors R3327-AT1. We also compare MR and electrode approaches to monitoring dynamic changes with respect to interventions and demonstrate extension of the MR technique to rat breast tumors.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalAdvances in experimental medicine and biology
Volume530
StatePublished - Nov 12 2003

Keywords

  • Echo planar imaging
  • Electrode
  • MRI
  • Oxygen
  • Prostate
  • Tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Mason, R. P., Hunjan, S., Constantinescu, A., Song, Y., Zhao, D., Hahn, E. W., Antich, P. P., & Peschke, P. (2003). Tumor oximetry: Comparison of 19F MR EPI and electrodes. Advances in experimental medicine and biology, 530, 19-27.