Tumor oxygen dynamics with respect to growth and respiratory challenge: Investigation of the Dunning prostate R3327-HI tumor

D. Zhao, A. Constantinescu, E. W. Hahn, R. P. Mason

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

We recently described a novel approach to measuring regional tumor oxygen tension using 19F nuclear magnetic resonance echo planar imaging relaxometry (FREDOM) of hexafluorobenzene. We have now applied this technique to evaluate in detail the oxygen tension dynamics in the relatively slowly growing, moderately well-differentiated Dunning prostate R3327 HI rat tumor with respect to tumor growth and respiratory challenge. Seven individual tumors were assessed repeatedly over a period of 5 weeks (∼4 volume doubling times). For small tumors (<1 cm3), the mean pO2 ranged from 28 to 44 Torr under baseline conditions, decreasing to less than 10 Torr when the tumors reached 5 to 6 cm3, with a strong inverse correlation between the baseline tumor oxygen tension and the tumor size. The hypoxic fraction (defined as the percentage of the voxels with pO2 <10 Torr) increased significantly with tumor growth. Administration of oxygen or carbogen produced a significant increase (P < 0.0001) in tumor oxygenation at all stages of tumor growth. Most interestingly, even regions of these tumors that were initially poorly oxygenated responded rapidly, and significantly, to respiratory intervention, in contrast to the behavior of the fastergrowing rat prostate tumors investigated previously.

Original languageEnglish (US)
Pages (from-to)510-520
Number of pages11
JournalRadiation Research
Volume156
Issue number5 I
StatePublished - 2001

Fingerprint

Prostate
tumors
Oxygen
oxygen
neoplasms
Growth
Neoplasms
oxygen tension
rats
Echo-Planar Imaging
prostatic neoplasms
oxygenation
nuclear magnetic resonance spectroscopy
echoes
Magnetic Resonance Spectroscopy
image analysis
nuclear magnetic resonance

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Tumor oxygen dynamics with respect to growth and respiratory challenge : Investigation of the Dunning prostate R3327-HI tumor. / Zhao, D.; Constantinescu, A.; Hahn, E. W.; Mason, R. P.

In: Radiation Research, Vol. 156, No. 5 I, 2001, p. 510-520.

Research output: Contribution to journalArticle

@article{1c6bbad690e24c7d8e3f1bcdd794fc2c,
title = "Tumor oxygen dynamics with respect to growth and respiratory challenge: Investigation of the Dunning prostate R3327-HI tumor",
abstract = "We recently described a novel approach to measuring regional tumor oxygen tension using 19F nuclear magnetic resonance echo planar imaging relaxometry (FREDOM) of hexafluorobenzene. We have now applied this technique to evaluate in detail the oxygen tension dynamics in the relatively slowly growing, moderately well-differentiated Dunning prostate R3327 HI rat tumor with respect to tumor growth and respiratory challenge. Seven individual tumors were assessed repeatedly over a period of 5 weeks (∼4 volume doubling times). For small tumors (<1 cm3), the mean pO2 ranged from 28 to 44 Torr under baseline conditions, decreasing to less than 10 Torr when the tumors reached 5 to 6 cm3, with a strong inverse correlation between the baseline tumor oxygen tension and the tumor size. The hypoxic fraction (defined as the percentage of the voxels with pO2 <10 Torr) increased significantly with tumor growth. Administration of oxygen or carbogen produced a significant increase (P < 0.0001) in tumor oxygenation at all stages of tumor growth. Most interestingly, even regions of these tumors that were initially poorly oxygenated responded rapidly, and significantly, to respiratory intervention, in contrast to the behavior of the fastergrowing rat prostate tumors investigated previously.",
author = "D. Zhao and A. Constantinescu and Hahn, {E. W.} and Mason, {R. P.}",
year = "2001",
language = "English (US)",
volume = "156",
pages = "510--520",
journal = "Radiation Research",
issn = "0033-7587",
publisher = "Radiation Research Society",
number = "5 I",

}

TY - JOUR

T1 - Tumor oxygen dynamics with respect to growth and respiratory challenge

T2 - Investigation of the Dunning prostate R3327-HI tumor

AU - Zhao, D.

AU - Constantinescu, A.

AU - Hahn, E. W.

AU - Mason, R. P.

PY - 2001

Y1 - 2001

N2 - We recently described a novel approach to measuring regional tumor oxygen tension using 19F nuclear magnetic resonance echo planar imaging relaxometry (FREDOM) of hexafluorobenzene. We have now applied this technique to evaluate in detail the oxygen tension dynamics in the relatively slowly growing, moderately well-differentiated Dunning prostate R3327 HI rat tumor with respect to tumor growth and respiratory challenge. Seven individual tumors were assessed repeatedly over a period of 5 weeks (∼4 volume doubling times). For small tumors (<1 cm3), the mean pO2 ranged from 28 to 44 Torr under baseline conditions, decreasing to less than 10 Torr when the tumors reached 5 to 6 cm3, with a strong inverse correlation between the baseline tumor oxygen tension and the tumor size. The hypoxic fraction (defined as the percentage of the voxels with pO2 <10 Torr) increased significantly with tumor growth. Administration of oxygen or carbogen produced a significant increase (P < 0.0001) in tumor oxygenation at all stages of tumor growth. Most interestingly, even regions of these tumors that were initially poorly oxygenated responded rapidly, and significantly, to respiratory intervention, in contrast to the behavior of the fastergrowing rat prostate tumors investigated previously.

AB - We recently described a novel approach to measuring regional tumor oxygen tension using 19F nuclear magnetic resonance echo planar imaging relaxometry (FREDOM) of hexafluorobenzene. We have now applied this technique to evaluate in detail the oxygen tension dynamics in the relatively slowly growing, moderately well-differentiated Dunning prostate R3327 HI rat tumor with respect to tumor growth and respiratory challenge. Seven individual tumors were assessed repeatedly over a period of 5 weeks (∼4 volume doubling times). For small tumors (<1 cm3), the mean pO2 ranged from 28 to 44 Torr under baseline conditions, decreasing to less than 10 Torr when the tumors reached 5 to 6 cm3, with a strong inverse correlation between the baseline tumor oxygen tension and the tumor size. The hypoxic fraction (defined as the percentage of the voxels with pO2 <10 Torr) increased significantly with tumor growth. Administration of oxygen or carbogen produced a significant increase (P < 0.0001) in tumor oxygenation at all stages of tumor growth. Most interestingly, even regions of these tumors that were initially poorly oxygenated responded rapidly, and significantly, to respiratory intervention, in contrast to the behavior of the fastergrowing rat prostate tumors investigated previously.

UR - http://www.scopus.com/inward/record.url?scp=0034760535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034760535&partnerID=8YFLogxK

M3 - Article

C2 - 11604064

AN - SCOPUS:0034760535

VL - 156

SP - 510

EP - 520

JO - Radiation Research

JF - Radiation Research

SN - 0033-7587

IS - 5 I

ER -