Tumor oxygen tension: Measurement using Oxygent® as a 19F NMR probe at 4.7 T

R. P. Mason, P. P. Antich

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We have used Oxygent® (an emulsion of perflubron [PFOB]) to measure pO2 in a Dunning prostatic adenocarcinoma non-invasively using 19F NMR spectroscopy. We have confirmed a linear relationship between the spin-lattice relaxation rate (R1) and pO2 and we have assessed the effect of temperature. R1 of the individual resonances of Oxygent is considerably more sensitive to changes in pO2 than other PFC emulsions, whilst being considerably less sensitive to interference from temperature variation. Oxygent has two well resolved resonances (Δδ ~ 18 ppm) and these were both exploited to estimate tumor pO2 = 47 ± 5 torr.

Original languageEnglish (US)
Pages (from-to)1361-1367
Number of pages7
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number4
StatePublished - 1994

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Emulsions
Tumors
Nuclear magnetic resonance
Oxygen
Spin-lattice relaxation
Nuclear magnetic resonance spectroscopy
Neoplasms
Temperature
Adenocarcinoma
Magnetic Resonance Spectroscopy
perflubron

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials
  • Hematology

Cite this

Tumor oxygen tension : Measurement using Oxygent® as a 19F NMR probe at 4.7 T. / Mason, R. P.; Antich, P. P.

In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, Vol. 22, No. 4, 1994, p. 1361-1367.

Research output: Contribution to journalArticle

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