TY - JOUR
T1 - Tumor oxygen tension
T2 - Measurement using oxygent as A19F nmr probe at 4.7 T
AU - Mason, R. P.
AU - Antich, P. P.
PY - 1994/1
Y1 - 1994/1
N2 - We have used Oxygent (an emulsion of perflubron [PFOB]) to measure pO2 in a Dunning prostatic adenocarcinoma noninvasively using 19F NMR spectroscopy. We have confirmed a linear relationship between the spin-lattice relaxation rate (R1) and pO2 and we have assessed the effect of temperature. R1 of the individual resonances of Oxygent is considerably more sensitive to changes in pO2 than other PFC emulsions, whilst being considerably less sensitive to interference from temperature variation. Oxygent has two well resolved resonances (A5 - 18ppm) and these were both exploited to estimate tumor p02=47+ 5 torr.
AB - We have used Oxygent (an emulsion of perflubron [PFOB]) to measure pO2 in a Dunning prostatic adenocarcinoma noninvasively using 19F NMR spectroscopy. We have confirmed a linear relationship between the spin-lattice relaxation rate (R1) and pO2 and we have assessed the effect of temperature. R1 of the individual resonances of Oxygent is considerably more sensitive to changes in pO2 than other PFC emulsions, whilst being considerably less sensitive to interference from temperature variation. Oxygent has two well resolved resonances (A5 - 18ppm) and these were both exploited to estimate tumor p02=47+ 5 torr.
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U2 - 10.3109/10731199409138838
DO - 10.3109/10731199409138838
M3 - Article
C2 - 7849945
AN - SCOPUS:0027978545
VL - 22
SP - 1361
EP - 1367
JO - Biomaterials, Artificial Cells, and Immobilization Biotechnology
JF - Biomaterials, Artificial Cells, and Immobilization Biotechnology
SN - 2169-1401
IS - 4
ER -