Tumor oxygen tension: Measurement using oxygent as A19F nmr probe at 4.7 T

R. P. Mason; P. P. Antich

doi:10.3109/10731199409138838

Tumor oxygen tension: Measurement using oxygent as A19F nmr probe at 4.7 T

R. P. Mason, P. P. Antich

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We have used Oxygent (an emulsion of perflubron [PFOB]) to measure pO2 in a Dunning prostatic adenocarcinoma noninvasively using 19F NMR spectroscopy. We have confirmed a linear relationship between the spin-lattice relaxation rate (R1) and pO2 and we have assessed the effect of temperature. R1 of the individual resonances of Oxygent is considerably more sensitive to changes in pO2 than other PFC emulsions, whilst being considerably less sensitive to interference from temperature variation. Oxygent has two well resolved resonances (A5 - 18ppm) and these were both exploited to estimate tumor p02=47+ 5 torr.

Original language	English (US)
Pages (from-to)	1361-1367
Number of pages	7
Journal	Artificial Cells, Blood Substitutes, and Biotechnology
Volume	22
Issue number	4
DOIs	https://doi.org/10.3109/10731199409138838
State	Published - Jan 1994

ASJC Scopus subject areas

Biotechnology
Biomedical Engineering

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title = "Tumor oxygen tension: Measurement using oxygent as A19F nmr probe at 4.7 T",

abstract = "We have used Oxygent (an emulsion of perflubron [PFOB]) to measure pO2 in a Dunning prostatic adenocarcinoma noninvasively using 19F NMR spectroscopy. We have confirmed a linear relationship between the spin-lattice relaxation rate (R1) and pO2 and we have assessed the effect of temperature. R1 of the individual resonances of Oxygent is considerably more sensitive to changes in pO2 than other PFC emulsions, whilst being considerably less sensitive to interference from temperature variation. Oxygent has two well resolved resonances (A5 - 18ppm) and these were both exploited to estimate tumor p02=47+ 5 torr.",

author = "Mason, {R. P.} and Antich, {P. P.}",

year = "1994",

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doi = "10.3109/10731199409138838",

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T1 - Tumor oxygen tension

T2 - Measurement using oxygent as A19F nmr probe at 4.7 T

AU - Mason, R. P.

AU - Antich, P. P.

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N2 - We have used Oxygent (an emulsion of perflubron [PFOB]) to measure pO2 in a Dunning prostatic adenocarcinoma noninvasively using 19F NMR spectroscopy. We have confirmed a linear relationship between the spin-lattice relaxation rate (R1) and pO2 and we have assessed the effect of temperature. R1 of the individual resonances of Oxygent is considerably more sensitive to changes in pO2 than other PFC emulsions, whilst being considerably less sensitive to interference from temperature variation. Oxygent has two well resolved resonances (A5 - 18ppm) and these were both exploited to estimate tumor p02=47+ 5 torr.

AB - We have used Oxygent (an emulsion of perflubron [PFOB]) to measure pO2 in a Dunning prostatic adenocarcinoma noninvasively using 19F NMR spectroscopy. We have confirmed a linear relationship between the spin-lattice relaxation rate (R1) and pO2 and we have assessed the effect of temperature. R1 of the individual resonances of Oxygent is considerably more sensitive to changes in pO2 than other PFC emulsions, whilst being considerably less sensitive to interference from temperature variation. Oxygent has two well resolved resonances (A5 - 18ppm) and these were both exploited to estimate tumor p02=47+ 5 torr.

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