Tumor suppressor interactions with microtubules: Keeping cell polarity and cell division on track

Paula Hernandez, Jennifer S. Tirnauer

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Tumor suppressor proteins protect cells and tissues from malignant transformation. Among their diverse actions, many of these proteins interact with the microtubule cytoskeleton. This review focuses on the interactions of several tumor suppressors with microtubules and speculates on how disruption of microtubule-dependent processes may contribute to cancer development and spread. We conclude that several tumor suppressors stabilize microtubules and organize microtubule arrays, functions that are likely to be important in preventing tumorigenesis. How tumor suppressors link microtubule stability with cell fate, and how their mutation affects the response of cancer cells to anti-microtubule chemotherapy drugs, remains unclear; these should prove fertile areas for future research.

Original languageEnglish (US)
Pages (from-to)304-315
Number of pages12
JournalDMM Disease Models and Mechanisms
Volume3
Issue number5-6
DOIs
StatePublished - May 2010
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Medicine (miscellaneous)
  • Immunology and Microbiology (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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