Tumor Vascularity in Renal Masses: Correlation of Arterial Spin-Labeled and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Assessments

Yue Zhang, Payal Kapur, Qing Yuan, Yin Xi, Ingrid Carvo, Sabina Signoretti, Ivan Dimitrov, Jeffrey A Cadeddu, Vitaly Margulis, Naira Muradyan, James B Brugarolas, Ananth J Madhuranthakam, Ivan Pedrosa

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Abstract

Background The objective of this study was to investigate potential correlations between perfusion using arterial spin-labeled (ASL) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE) MRI-derived quantitative measures of vascularity in renal masses > 2 cm and to correlate these with microvessel density (MVD) in clear cell renal cell carcinoma (ccRCC). Patients and Methods Informed written consent was obtained from all patients before imaging in this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved, prospective study. Thirty-six consecutive patients scheduled for surgery of a known renal mass > 2 cm underwent 3T ASL and DCE MRI. ASL perfusion measures (PASL) of mean, peak, and low perfusion areas within the mass were correlated to DCE-derived volume transfer constant (Ktrans), rate constant (Kep), and fractional volume of the extravascular extracellular space (Ve) in the same locations using a region of interest analysis. MRI data were correlated to MVD measures in the same tumor regions in ccRCC. Spearman correlation was used to evaluate the correlation between PASL and DCE-derived measurements, and MVD. P ASL correlated with Ktrans (ρ = 0.48 and P =.0091 for the entire tumor and ρ = 0.43 and P =.03 for the high flow area, respectively) and Kep (ρ = 0.46 and P =.01 for the entire tumor and ρ = 0.52 and P =.008 for the high flow area, respectively). PASL (ρ = 0.66; P =.0002), Ktrans (ρ = 0.61; P =.001), and Kep (ρ = 0.64; P =.0006) also correlated with MVD in high and low perfusion areas in ccRCC. Conclusion PASL correlated with the DCE-derived measures of vascular permeability and flow, Ktrans and Kep, in renal masses > 2 cm in size. Both measures correlated to MVD in clear cell histology.

Original languageEnglish (US)
Pages (from-to)e25-e36
JournalClinical Genitourinary Cancer
Volume14
Issue number1
DOIs
StatePublished - Feb 1 2016

Fingerprint

Microvessels
Magnetic Resonance Imaging
Kidney
Perfusion
Renal Cell Carcinoma
Neoplasms
Health Insurance Portability and Accountability Act
Research Ethics Committees
Extracellular Space
Capillary Permeability
Informed Consent
Histology
Prospective Studies

Keywords

  • Angiogenesis
  • Arterial spin labeling
  • Dynamic contrast-enhanced MRI
  • Kidney cancers
  • Microvessel density

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

@article{7fbc4461e9064e1b98cd8b0cdac106be,
title = "Tumor Vascularity in Renal Masses: Correlation of Arterial Spin-Labeled and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Assessments",
abstract = "Background The objective of this study was to investigate potential correlations between perfusion using arterial spin-labeled (ASL) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE) MRI-derived quantitative measures of vascularity in renal masses > 2 cm and to correlate these with microvessel density (MVD) in clear cell renal cell carcinoma (ccRCC). Patients and Methods Informed written consent was obtained from all patients before imaging in this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved, prospective study. Thirty-six consecutive patients scheduled for surgery of a known renal mass > 2 cm underwent 3T ASL and DCE MRI. ASL perfusion measures (PASL) of mean, peak, and low perfusion areas within the mass were correlated to DCE-derived volume transfer constant (Ktrans), rate constant (Kep), and fractional volume of the extravascular extracellular space (Ve) in the same locations using a region of interest analysis. MRI data were correlated to MVD measures in the same tumor regions in ccRCC. Spearman correlation was used to evaluate the correlation between PASL and DCE-derived measurements, and MVD. P ASL correlated with Ktrans (ρ = 0.48 and P =.0091 for the entire tumor and ρ = 0.43 and P =.03 for the high flow area, respectively) and Kep (ρ = 0.46 and P =.01 for the entire tumor and ρ = 0.52 and P =.008 for the high flow area, respectively). PASL (ρ = 0.66; P =.0002), Ktrans (ρ = 0.61; P =.001), and Kep (ρ = 0.64; P =.0006) also correlated with MVD in high and low perfusion areas in ccRCC. Conclusion PASL correlated with the DCE-derived measures of vascular permeability and flow, Ktrans and Kep, in renal masses > 2 cm in size. Both measures correlated to MVD in clear cell histology.",
keywords = "Angiogenesis, Arterial spin labeling, Dynamic contrast-enhanced MRI, Kidney cancers, Microvessel density",
author = "Yue Zhang and Payal Kapur and Qing Yuan and Yin Xi and Ingrid Carvo and Sabina Signoretti and Ivan Dimitrov and Cadeddu, {Jeffrey A} and Vitaly Margulis and Naira Muradyan and Brugarolas, {James B} and Madhuranthakam, {Ananth J} and Ivan Pedrosa",
year = "2016",
month = "2",
day = "1",
doi = "10.1016/j.clgc.2015.08.007",
language = "English (US)",
volume = "14",
pages = "e25--e36",
journal = "Clinical Genitourinary Cancer",
issn = "1558-7673",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Tumor Vascularity in Renal Masses

T2 - Correlation of Arterial Spin-Labeled and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Assessments

AU - Zhang, Yue

AU - Kapur, Payal

AU - Yuan, Qing

AU - Xi, Yin

AU - Carvo, Ingrid

AU - Signoretti, Sabina

AU - Dimitrov, Ivan

AU - Cadeddu, Jeffrey A

AU - Margulis, Vitaly

AU - Muradyan, Naira

AU - Brugarolas, James B

AU - Madhuranthakam, Ananth J

AU - Pedrosa, Ivan

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background The objective of this study was to investigate potential correlations between perfusion using arterial spin-labeled (ASL) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE) MRI-derived quantitative measures of vascularity in renal masses > 2 cm and to correlate these with microvessel density (MVD) in clear cell renal cell carcinoma (ccRCC). Patients and Methods Informed written consent was obtained from all patients before imaging in this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved, prospective study. Thirty-six consecutive patients scheduled for surgery of a known renal mass > 2 cm underwent 3T ASL and DCE MRI. ASL perfusion measures (PASL) of mean, peak, and low perfusion areas within the mass were correlated to DCE-derived volume transfer constant (Ktrans), rate constant (Kep), and fractional volume of the extravascular extracellular space (Ve) in the same locations using a region of interest analysis. MRI data were correlated to MVD measures in the same tumor regions in ccRCC. Spearman correlation was used to evaluate the correlation between PASL and DCE-derived measurements, and MVD. P ASL correlated with Ktrans (ρ = 0.48 and P =.0091 for the entire tumor and ρ = 0.43 and P =.03 for the high flow area, respectively) and Kep (ρ = 0.46 and P =.01 for the entire tumor and ρ = 0.52 and P =.008 for the high flow area, respectively). PASL (ρ = 0.66; P =.0002), Ktrans (ρ = 0.61; P =.001), and Kep (ρ = 0.64; P =.0006) also correlated with MVD in high and low perfusion areas in ccRCC. Conclusion PASL correlated with the DCE-derived measures of vascular permeability and flow, Ktrans and Kep, in renal masses > 2 cm in size. Both measures correlated to MVD in clear cell histology.

AB - Background The objective of this study was to investigate potential correlations between perfusion using arterial spin-labeled (ASL) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE) MRI-derived quantitative measures of vascularity in renal masses > 2 cm and to correlate these with microvessel density (MVD) in clear cell renal cell carcinoma (ccRCC). Patients and Methods Informed written consent was obtained from all patients before imaging in this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved, prospective study. Thirty-six consecutive patients scheduled for surgery of a known renal mass > 2 cm underwent 3T ASL and DCE MRI. ASL perfusion measures (PASL) of mean, peak, and low perfusion areas within the mass were correlated to DCE-derived volume transfer constant (Ktrans), rate constant (Kep), and fractional volume of the extravascular extracellular space (Ve) in the same locations using a region of interest analysis. MRI data were correlated to MVD measures in the same tumor regions in ccRCC. Spearman correlation was used to evaluate the correlation between PASL and DCE-derived measurements, and MVD. P ASL correlated with Ktrans (ρ = 0.48 and P =.0091 for the entire tumor and ρ = 0.43 and P =.03 for the high flow area, respectively) and Kep (ρ = 0.46 and P =.01 for the entire tumor and ρ = 0.52 and P =.008 for the high flow area, respectively). PASL (ρ = 0.66; P =.0002), Ktrans (ρ = 0.61; P =.001), and Kep (ρ = 0.64; P =.0006) also correlated with MVD in high and low perfusion areas in ccRCC. Conclusion PASL correlated with the DCE-derived measures of vascular permeability and flow, Ktrans and Kep, in renal masses > 2 cm in size. Both measures correlated to MVD in clear cell histology.

KW - Angiogenesis

KW - Arterial spin labeling

KW - Dynamic contrast-enhanced MRI

KW - Kidney cancers

KW - Microvessel density

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U2 - 10.1016/j.clgc.2015.08.007

DO - 10.1016/j.clgc.2015.08.007

M3 - Article

C2 - 26422014

AN - SCOPUS:84951745305

VL - 14

SP - e25-e36

JO - Clinical Genitourinary Cancer

JF - Clinical Genitourinary Cancer

SN - 1558-7673

IS - 1

ER -