Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment

Denise A. Chan, Tiara L A Kawahara, Patrick D. Sutphin, Howard Y. Chang, Jen Tsan Chi, Amato J. Giaccia

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Sustained angiogenesis, through either local sprouting (angiogenesis) or the recruitment of bone marrow-derived cells (BMDCs) (vasculogenesis), is essential to the development of a tumor. How BMDCs are recruited to the tumor and their contribution to the tumor vasculature is poorly understood. Here, we demonstrate that both IL-8 and angiogenin contribute to the complementary pathways of angiogenesis and BMDC mobilization to increase tumor growth. These two factors are regulated by PHD2 in a HIF-independent but NF-κB-dependent manner. PHD2 levels are decreased in human cancers, compared with corresponding normal tissue, and correlate with an increase in mature blood vessels. Thus, PHD2 plays a critical role in regulating tumor angiogenesis.

Original languageEnglish (US)
Pages (from-to)527-538
Number of pages12
JournalCancer Cell
Volume15
Issue number6
DOIs
StatePublished - Jun 2 2009

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Bone Marrow Cells
Neoplasms
Interleukin-8
Blood Vessels
Growth

Keywords

  • CELLCYCLE

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Chan, D. A., Kawahara, T. L. A., Sutphin, P. D., Chang, H. Y., Chi, J. T., & Giaccia, A. J. (2009). Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment. Cancer Cell, 15(6), 527-538. https://doi.org/10.1016/j.ccr.2009.04.010

Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment. / Chan, Denise A.; Kawahara, Tiara L A; Sutphin, Patrick D.; Chang, Howard Y.; Chi, Jen Tsan; Giaccia, Amato J.

In: Cancer Cell, Vol. 15, No. 6, 02.06.2009, p. 527-538.

Research output: Contribution to journalArticle

Chan, DA, Kawahara, TLA, Sutphin, PD, Chang, HY, Chi, JT & Giaccia, AJ 2009, 'Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment', Cancer Cell, vol. 15, no. 6, pp. 527-538. https://doi.org/10.1016/j.ccr.2009.04.010
Chan, Denise A. ; Kawahara, Tiara L A ; Sutphin, Patrick D. ; Chang, Howard Y. ; Chi, Jen Tsan ; Giaccia, Amato J. / Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment. In: Cancer Cell. 2009 ; Vol. 15, No. 6. pp. 527-538.
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