Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Hartmut Land, Luis F. Parada, Robert A. Weinberg

Research output: Contribution to journalArticle

1878 Scopus citations

Abstract

Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.

Original languageEnglish (US)
Pages (from-to)596-602
Number of pages7
JournalNature
Volume304
Issue number5927
DOIs
StatePublished - Dec 1 1983

ASJC Scopus subject areas

  • General

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