Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells

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286 Citations (Scopus)

Abstract

Switch it up: Tunable, pH-responsive nanoparticles can be selectively activated in different endocytic compartments. At high pHvalues, micelle formation (see picture, left) quenches fluorescence by Förster resonance energy transfer. The micelles disassemble at low pHvalues, leading to fluorescence emission. This nonlinear on/off nanoplatform offers many exciting opportunities in diagnostic imaging and drug-delivery applications.

Original languageEnglish (US)
Pages (from-to)6109-6114
Number of pages6
JournalAngewandte Chemie - International Edition
Volume50
Issue number27
DOIs
StatePublished - Jun 27 2011

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Micelles
Fluorescence
Cells
Nanoparticles
Drug delivery
Energy transfer
Switches
Imaging techniques

Keywords

  • cell cycle
  • fluorescent probes
  • micelles
  • nanostructures
  • pH activation

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

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abstract = "Switch it up: Tunable, pH-responsive nanoparticles can be selectively activated in different endocytic compartments. At high pHvalues, micelle formation (see picture, left) quenches fluorescence by F{\"o}rster resonance energy transfer. The micelles disassemble at low pHvalues, leading to fluorescence emission. This nonlinear on/off nanoplatform offers many exciting opportunities in diagnostic imaging and drug-delivery applications.",
keywords = "cell cycle, fluorescent probes, micelles, nanostructures, pH activation",
author = "Kejin Zhou and Yiguang Wang and Xiaonan Huang and Katherine Luby-Phelps and Sumer, {Baran D.} and Jinming Gao",
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AU - Zhou, Kejin

AU - Wang, Yiguang

AU - Huang, Xiaonan

AU - Luby-Phelps, Katherine

AU - Sumer, Baran D.

AU - Gao, Jinming

PY - 2011/6/27

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KW - fluorescent probes

KW - micelles

KW - nanostructures

KW - pH activation

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