Tuning the In Vivo Transport of Anticancer Drugs Using Renal-Clearable Gold Nanoparticles

Chuanqi Peng, Jing Xu, Mengxiao Yu, Xuhui Ning, Yingyu Huang, Bujie Du, Elizabeth Hernandez, Payal Kapur, Jer-Tsong Hsieh, Jie Zheng

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Precise control of in vivo transport of anticancer drugs in normal and cancerous tissues with engineered nanoparticles is key to the future success of cancer nanomedicines in clinics. This requires a fundamental understanding of how engineered nanoparticles impact the targeting-clearance and permeation-retention paradoxes in the anticancer-drug delivery. Herein, we systematically investigated how renal-clearable gold nanoparticles (AuNPs) affect the permeation, distribution, and retention of the anticancer drug doxorubicin in both cancerous and normal tissues. Renal-clearable AuNPs retain the advantages of the free drug, including rapid tumor targeting and high tumor vascular permeability. The renal-clearable AuNPs also accelerated body clearance of off-target drug via renal elimination. These results clearly indicate that diverse in vivo transport behaviors of engineered nanoparticles can be used to reconcile long-standing paradoxes in the anticancer drug delivery.

Original languageEnglish (US)
JournalAngewandte Chemie - International Edition
DOIs
StatePublished - Jan 1 2019

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Keywords

  • drug delivery
  • enhanced permeability and retention effect
  • gold nanoparticles
  • renal clearance
  • tumor targeting

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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