Turnabout is fair play: Use of the bacterial multivalent adhesion molecule 7 as an antimicrobial agent

Anne Marie Krachler, Hyeilin Ham, Kim Orth

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Pathogen attachment to host tissues is one of the initial and most crucial events during the establishment of bacterial infections and thus interference with this step could be an efficient strategy to fight bacterial colonization. Our recent work has identified one of the factors involved in initial binding of host cells by a wide range of Gram-negative pathogens, Multivalent Adhesion Molecule (MAM) 7. Interference with MAM7- mediated attachment, for example by pre-incubation of host cells with recombinant MAM7, significantly delays the onset of hallmarks of infection, such as pathogen-mediated cytotoxicity or the development of other adhesive structures such as actin pedestals. Thus, we are trying to develop tools based on MAM7 that can be used to prevent or diminish certain Gram-negative bacterial infections. Herein, we describe the use of bead-coupled MAM7 as an inhibitor of infection with the clinically relevant pathogen Pseudomonas aeruginosa.

Original languageEnglish (US)
Pages (from-to)68-71
Number of pages4
JournalVirulence
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • Adhesin
  • Anti- adhesion therapy
  • Attachment
  • Fibronectin
  • Gramnegative pathogen
  • Infection
  • Phosphatidic acid

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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