Turnover of low density lipoproteins during inhibition of cholesterol absorption by neomycin

Y. A. Kesaniemi, Scott M Grundy

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The mechanisms for the hypocholesterolemic action of neomycin were examined in 6 patients with various levels of plasma total cholesterol and triglycerides. All patients were studied on a metabolic ward. The first period of 6 weeks was for control. Thereafter, neomycin (1.5 g/day) was started, and the patients were readmitted for another 6-week period after 2 to 3 months of treatment with the drug. Cholesterol balance studies showed that neomycin increased fecal excretion of neutral steroids by an average of 45%; the drug also inhibited absorption of exogenous cholesterol by an average of 44%. During treatment with neomycin, the plasma total cholesterol fell by an average of 20%, low density lipoproteins (LDL) fell by 25%, and high density lipoproteins, by 16%. Neomycin did not change plasma triglyceride levels. Turnover of the apoprotein of LDL (apoLDL) was measured following injection of 125I-apoLDL. Neomycin decreased synthesis of apoLDL by 28%. The decrease in plasma apoLDL level was correlated positively with the decrease in apoLDL synthetic rate. The effect of the drug on clearance of LDL was less constant; 4 of 6 patients had an increase in fractional clearance rates of apoLDL, but the change for the whole group was not statistically significant. These data suggest that a decrease in production of LDL is a major factor in the lowering of LDL following inhibition of cholesterol absorption; however, an increase in clearance rates may occur in some patients.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalArteriosclerosis
Volume4
Issue number1
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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