Twenty-four hour growth hormone secretion in a patient with Werner's syndrome

Craig D. Rubin, Berenice Reed

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective: to assess the 24-h endogenous secretory growth hormone (GH) profile and serum insulin-like growth factor-I (IGF-I) response to exogenous recombinant human growth hormone (rhGH) in a patient with Werner's syndrome. Design: blood sampling every 20 min for 24 h followed by three daily injections of growth hormone. Setting: General Clinical Research Center. Patients: single patient with Werner's syndrome. Measurements: serum GH and IGF-I. Results: Growth hormone pulses were absent during the 24-h monitoring period. Likewise, integrated GH concentrations were very low at 0.25 μ·min/mL, and no peaks occurred after sleep onset. Following single daily administration of rhGH, serum GH and IGF-I rose. Conclusions: our findings support previous but less extensive studies suggesting patients with Werner's syndrome have reduced growth hormone levels. Preliminary investigations using rhGH in patients with Werner's syndrome should be considered.

Original languageEnglish (US)
Pages (from-to)557-561
Number of pages5
JournalExperimental Gerontology
Volume31
Issue number5
DOIs
StatePublished - Jan 1 1996

Keywords

  • IGF-I
  • Werner's
  • accelerated aging
  • genetic syndromes
  • growth hormone
  • premature aging syndrome

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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