TWO CASES of ACUTE RETINAL NECROSIS DUE to VARICELLA ZOSTER DESPITE PRIOR SHINGLES VACCINATION

Eric J. Weinlander; Angeline L. Wang; Pimkwan Jaru-Ampornpan; Michael M. Altaweel; T. Michael Nork

doi:10.1097/ICB.0000000000000567

TWO CASES of ACUTE RETINAL NECROSIS DUE to VARICELLA ZOSTER DESPITE PRIOR SHINGLES VACCINATION

Eric J. Weinlander, Angeline L. Wang, Pimkwan Jaru-Ampornpan, Michael M. Altaweel, T. Michael Nork

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose:To review two cases of acute retinal necrosis in adults due to varicella zoster virus despite prior shingles vaccination.Methods:Retrospective chart review.Patients:A 62-year-old man and a 64-year-old man with unilateral acute retinal necrosis who had shingles vaccinations 16 and 7 months before their ocular symptoms.Results:Polymerase chain reaction confirmation of varicella zoster virus in the anterior chambers of both patients. Both patients had good responses to oral antiviral therapy and topical and/or oral steroids.Discussion:These two cases demonstrate that singles vaccination is not an absolute protection against varicella zoster virus-related acute retinal necrosis. However, such vaccination may reduce the severity of the acute retinal necrosis.

Original language	English (US)
Pages (from-to)	241-243
Number of pages	3
Journal	Retinal Cases and Brief Reports
Volume	13
Issue number	3
DOIs	https://doi.org/10.1097/ICB.0000000000000567
State	Published - Jun 1 2019
Externally published	Yes

Keywords

acute retinal necrosis
prior shingles vaccination
varicella zoster virus

ASJC Scopus subject areas

Ophthalmology

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title = "TWO CASES of ACUTE RETINAL NECROSIS DUE to VARICELLA ZOSTER DESPITE PRIOR SHINGLES VACCINATION",

abstract = "Purpose:To review two cases of acute retinal necrosis in adults due to varicella zoster virus despite prior shingles vaccination.Methods:Retrospective chart review.Patients:A 62-year-old man and a 64-year-old man with unilateral acute retinal necrosis who had shingles vaccinations 16 and 7 months before their ocular symptoms.Results:Polymerase chain reaction confirmation of varicella zoster virus in the anterior chambers of both patients. Both patients had good responses to oral antiviral therapy and topical and/or oral steroids.Discussion:These two cases demonstrate that singles vaccination is not an absolute protection against varicella zoster virus-related acute retinal necrosis. However, such vaccination may reduce the severity of the acute retinal necrosis.",

keywords = "acute retinal necrosis, prior shingles vaccination, varicella zoster virus",

author = "Weinlander, {Eric J.} and Wang, {Angeline L.} and Pimkwan Jaru-Ampornpan and Altaweel, {Michael M.} and Nork, {T. Michael}",

note = "Funding Information: Supported by Research to Prevent Blindness, National Institutes of Health (NIH) P30 EY016665, and McPherson Eye Research Institute{\textquoteright}s Retina Research Foundation Kathryn & Latimer Murfee Chair. None of the authors has any conflicting interests to disclose.",

year = "2019",

month = jun,

day = "1",

doi = "10.1097/ICB.0000000000000567",

language = "English (US)",

volume = "13",

pages = "241--243",

journal = "Retinal Cases and Brief Reports",

issn = "1935-1089",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

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T1 - TWO CASES of ACUTE RETINAL NECROSIS DUE to VARICELLA ZOSTER DESPITE PRIOR SHINGLES VACCINATION

AU - Weinlander, Eric J.

AU - Wang, Angeline L.

AU - Jaru-Ampornpan, Pimkwan

AU - Altaweel, Michael M.

AU - Nork, T. Michael

N1 - Funding Information: Supported by Research to Prevent Blindness, National Institutes of Health (NIH) P30 EY016665, and McPherson Eye Research Institute’s Retina Research Foundation Kathryn & Latimer Murfee Chair. None of the authors has any conflicting interests to disclose.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Purpose:To review two cases of acute retinal necrosis in adults due to varicella zoster virus despite prior shingles vaccination.Methods:Retrospective chart review.Patients:A 62-year-old man and a 64-year-old man with unilateral acute retinal necrosis who had shingles vaccinations 16 and 7 months before their ocular symptoms.Results:Polymerase chain reaction confirmation of varicella zoster virus in the anterior chambers of both patients. Both patients had good responses to oral antiviral therapy and topical and/or oral steroids.Discussion:These two cases demonstrate that singles vaccination is not an absolute protection against varicella zoster virus-related acute retinal necrosis. However, such vaccination may reduce the severity of the acute retinal necrosis.

AB - Purpose:To review two cases of acute retinal necrosis in adults due to varicella zoster virus despite prior shingles vaccination.Methods:Retrospective chart review.Patients:A 62-year-old man and a 64-year-old man with unilateral acute retinal necrosis who had shingles vaccinations 16 and 7 months before their ocular symptoms.Results:Polymerase chain reaction confirmation of varicella zoster virus in the anterior chambers of both patients. Both patients had good responses to oral antiviral therapy and topical and/or oral steroids.Discussion:These two cases demonstrate that singles vaccination is not an absolute protection against varicella zoster virus-related acute retinal necrosis. However, such vaccination may reduce the severity of the acute retinal necrosis.

KW - acute retinal necrosis

KW - prior shingles vaccination

KW - varicella zoster virus

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TWO CASES of ACUTE RETINAL NECROSIS DUE to VARICELLA ZOSTER DESPITE PRIOR SHINGLES VACCINATION

Abstract

Keywords

ASJC Scopus subject areas

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