Two cases of intoxication with new synthetic opioid, U-47700

K. Domanski, K. C. Kleinschmidt, J. M. Schulte, S. Fleming, C. Frazee, A. Menendez, K. Tavakoli

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Background: Novel substances often referred to as “designer drugs” have emerged as drugs of abuse, and recognition of these is difficult as routine blood and urine screening tests do not detect these agents. U-47700 is a synthetic selective μ-opioid agonist that can be bought online for as little as $40 per gram. We report two patients presenting after insufflation of U-47700, with subsequent confirmation of this substance in urine samples. Case details: A 26-year-old man and 24-year-old woman insufflated a substance they believed to be “synthetic cocaine.” The man was found down with cyanosis and agonal respirations. He was intubated and taken to hospital where he recovered well with supportive care. The woman presented with anxiety, tremors and drowsiness and was admitted for observation. Urine samples from both patients were analyzed using GC/MS/MS and LC/QToF, and U-47700 was isolated in both cases. No other opioids were detected. Discussion: These cases are concerning because U-47700 is a relatively new agent that is easy to obtain over the internet and has the potential to cause significant morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalClinical Toxicology
DOIs
StateAccepted/In press - Jul 18 2016

Keywords

  • drugs of abuse
  • New psychoactive substances
  • research chemical

ASJC Scopus subject areas

  • Toxicology

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    Domanski, K., Kleinschmidt, K. C., Schulte, J. M., Fleming, S., Frazee, C., Menendez, A., & Tavakoli, K. (Accepted/In press). Two cases of intoxication with new synthetic opioid, U-47700. Clinical Toxicology, 1-5. https://doi.org/10.1080/15563650.2016.1209763