Two-component approach toward a fully substituted N-fused pyrrole ring

Dmitri Chernyak, Cathy Skontos, Vladimir Gevorgyan

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

(Figure Presented) An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by the 5-endo-dig cyclization leading to highly functionalized pyrroloheterocycles in good to excellent yield.

Original languageEnglish (US)
Pages (from-to)3242-3245
Number of pages4
JournalOrganic Letters
Volume12
Issue number14
DOIs
StatePublished - Jul 16 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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