Two-component approach toward a fully substituted N-fused pyrrole ring

Dmitri Chernyak; Cathy Skontos; Vladimir Gevorgyan

doi:10.1021/ol1011949

Two-component approach toward a fully substituted N-fused pyrrole ring

Dmitri Chernyak, Cathy Skontos, Vladimir Gevorgyan

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

(Figure Presented) An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by the 5-endo-dig cyclization leading to highly functionalized pyrroloheterocycles in good to excellent yield.

Original language	English (US)
Pages (from-to)	3242-3245
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	14
DOIs	https://doi.org/10.1021/ol1011949
State	Published - Jul 16 2010
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol1011949

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abstract = "(Figure Presented) An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by the 5-endo-dig cyclization leading to highly functionalized pyrroloheterocycles in good to excellent yield.",

author = "Dmitri Chernyak and Cathy Skontos and Vladimir Gevorgyan",

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doi = "10.1021/ol1011949",

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AU - Chernyak, Dmitri

AU - Skontos, Cathy

AU - Gevorgyan, Vladimir

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N2 - (Figure Presented) An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by the 5-endo-dig cyclization leading to highly functionalized pyrroloheterocycles in good to excellent yield.

AB - (Figure Presented) An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by the 5-endo-dig cyclization leading to highly functionalized pyrroloheterocycles in good to excellent yield.

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Two-component approach toward a fully substituted N-fused pyrrole ring

Abstract

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