Two different forms of endothelin receptors in rat lung

Yasushi Masuda, Hitoshi Miyazaki, Motohiro Kondoh, Hirotoshi Watanabe, Masashi Yanagisawa, Tomoh Masaki, Kazuo Murakami

Research output: Contribution to journalArticle

107 Scopus citations

Abstract

We provided evidence for the presence of two distinct types of rat endothelin (ET) receptors having different molecular masses by affinity labelling of rat lung membranes with 125I-ET-1, ET-2 and ET-3 and SDS-PAGE followed by autoradiography. One type, which is 44 kDa has a higher affinity for ET-1 and -2 than ET-3, whereas the other type, which is 32 kDa, preferably interacts with ET-3 rather than ET-1 and -2.

Original languageEnglish (US)
Pages (from-to)208-210
Number of pages3
JournalFEBS Letters
Volume257
Issue number2
DOIs
StatePublished - Nov 6 1989

Keywords

  • Affinity labelling
  • Endothelin
  • Endothelin receptor
  • Receptor subtype

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Masuda, Y., Miyazaki, H., Kondoh, M., Watanabe, H., Yanagisawa, M., Masaki, T., & Murakami, K. (1989). Two different forms of endothelin receptors in rat lung. FEBS Letters, 257(2), 208-210. https://doi.org/10.1016/0014-5793(89)81535-2