Abstract
We provided evidence for the presence of two distinct types of rat endothelin (ET) receptors having different molecular masses by affinity labelling of rat lung membranes with 125I-ET-1, ET-2 and ET-3 and SDS-PAGE followed by autoradiography. One type, which is 44 kDa has a higher affinity for ET-1 and -2 than ET-3, whereas the other type, which is 32 kDa, preferably interacts with ET-3 rather than ET-1 and -2.
Original language | English (US) |
---|---|
Pages (from-to) | 208-210 |
Number of pages | 3 |
Journal | FEBS Letters |
Volume | 257 |
Issue number | 2 |
DOIs | |
State | Published - Nov 6 1989 |
Keywords
- Affinity labelling
- Endothelin
- Endothelin receptor
- Receptor subtype
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology