Two fatty acids can replace one phospholipid in condensed complexes with cholesterol

Tamara M. Okonogi; Arun Radhakrishnan; Harden M. McConnell

doi:10.1016/S0005-2736(02)00451-0

Two fatty acids can replace one phospholipid in condensed complexes with cholesterol

Tamara M. Okonogi, Arun Radhakrishnan, Harden M. McConnell

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We report that the monolayer phase diagram for binary mixtures of dimyristoylphosphatidylethanolamine (DMPE) and dihydrocholesterol (DChol) is largely unchanged when each phospholipid molecule is replaced by two myristic acid (MA) molecules or various mixtures of the lysophospholipid and myristic acid. The corresponding phase diagrams all show the formation of "condensed complexes" of DChol and lipid. The condensed complex stoichiometry is thus largely determined by the C14 fatty acid acyl chains, in this case about 4-4.6 per DChol molecule.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	1564
Issue number	1
DOIs	https://doi.org/10.1016/S0005-2736(02)00451-0
State	Published - Aug 19 2002

Keywords

Acyl chain
Glycerol backbone
Lysophospholipid
Membrane structure
Monolayer
Phase diagram

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

Access to Document

10.1016/S0005-2736(02)00451-0

Cite this

@article{e978df0078d64de2800df5408bbfb955,

title = "Two fatty acids can replace one phospholipid in condensed complexes with cholesterol",

abstract = "We report that the monolayer phase diagram for binary mixtures of dimyristoylphosphatidylethanolamine (DMPE) and dihydrocholesterol (DChol) is largely unchanged when each phospholipid molecule is replaced by two myristic acid (MA) molecules or various mixtures of the lysophospholipid and myristic acid. The corresponding phase diagrams all show the formation of {"}condensed complexes{"} of DChol and lipid. The condensed complex stoichiometry is thus largely determined by the C14 fatty acid acyl chains, in this case about 4-4.6 per DChol molecule.",

keywords = "Acyl chain, Glycerol backbone, Lysophospholipid, Membrane structure, Monolayer, Phase diagram",

author = "Okonogi, {Tamara M.} and Arun Radhakrishnan and McConnell, {Harden M.}",

note = "Funding Information: This work was supported by the NIH.",

year = "2002",

month = aug,

day = "19",

doi = "10.1016/S0005-2736(02)00451-0",

language = "English (US)",

volume = "1564",

pages = "1--4",

journal = "Biochimica et Biophysica Acta - Biomembranes",

issn = "0005-2736",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Two fatty acids can replace one phospholipid in condensed complexes with cholesterol

AU - Okonogi, Tamara M.

AU - Radhakrishnan, Arun

AU - McConnell, Harden M.

N1 - Funding Information: This work was supported by the NIH.

PY - 2002/8/19

Y1 - 2002/8/19

N2 - We report that the monolayer phase diagram for binary mixtures of dimyristoylphosphatidylethanolamine (DMPE) and dihydrocholesterol (DChol) is largely unchanged when each phospholipid molecule is replaced by two myristic acid (MA) molecules or various mixtures of the lysophospholipid and myristic acid. The corresponding phase diagrams all show the formation of "condensed complexes" of DChol and lipid. The condensed complex stoichiometry is thus largely determined by the C14 fatty acid acyl chains, in this case about 4-4.6 per DChol molecule.

AB - We report that the monolayer phase diagram for binary mixtures of dimyristoylphosphatidylethanolamine (DMPE) and dihydrocholesterol (DChol) is largely unchanged when each phospholipid molecule is replaced by two myristic acid (MA) molecules or various mixtures of the lysophospholipid and myristic acid. The corresponding phase diagrams all show the formation of "condensed complexes" of DChol and lipid. The condensed complex stoichiometry is thus largely determined by the C14 fatty acid acyl chains, in this case about 4-4.6 per DChol molecule.

KW - Acyl chain

KW - Glycerol backbone

KW - Lysophospholipid

KW - Membrane structure

KW - Monolayer

KW - Phase diagram

UR - http://www.scopus.com/inward/record.url?scp=0037136069&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037136069&partnerID=8YFLogxK

U2 - 10.1016/S0005-2736(02)00451-0

DO - 10.1016/S0005-2736(02)00451-0

M3 - Article

C2 - 12100988

AN - SCOPUS:0037136069

SN - 0005-2736

VL - 1564

SP - 1

EP - 4

JO - Biochimica et Biophysica Acta - Biomembranes

JF - Biochimica et Biophysica Acta - Biomembranes

IS - 1

ER -

Two fatty acids can replace one phospholipid in condensed complexes with cholesterol

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this