Two fatty acids can replace one phospholipid in condensed complexes with cholesterol

Tamara M. Okonogi, Arun Radhakrishnan, Harden M. McConnell

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We report that the monolayer phase diagram for binary mixtures of dimyristoylphosphatidylethanolamine (DMPE) and dihydrocholesterol (DChol) is largely unchanged when each phospholipid molecule is replaced by two myristic acid (MA) molecules or various mixtures of the lysophospholipid and myristic acid. The corresponding phase diagrams all show the formation of "condensed complexes" of DChol and lipid. The condensed complex stoichiometry is thus largely determined by the C14 fatty acid acyl chains, in this case about 4-4.6 per DChol molecule.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1564
Issue number1
DOIs
StatePublished - Aug 19 2002

Keywords

  • Acyl chain
  • Glycerol backbone
  • Lysophospholipid
  • Membrane structure
  • Monolayer
  • Phase diagram

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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