TY - JOUR
T1 - Two novel high performing composite PMMA-CaP cements for vertebroplasty
T2 - An ex vivo animal study
AU - Aghyarian, Shant
AU - Hu, Xiaobang
AU - Lieberman, Isador H.
AU - Kosmopoulos, Victor
AU - Kim, Harry K W
AU - Rodrigues, Danieli C.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - There is a growing body of the literature on new cement formulations that address the shortcomings of PMMA bone cements approved for use in vertebroplasty (VP) and balloon kyphoplasty (BKP). The present study is a contribution to these efforts by further characterization of two pre-mixed CaP filler-reinforced PMMA bone cements intended for VP; namely, PMMA-HA and PMMA-brushite cements. Each of these cements showed acceptable levels of various properties determined in porcine vertebral bodies. These properties included radiographic contrast, maximum exotherm temperature setting time, cement extravasation, stiffness change after fatigue loading, change of VB height after fracture following fatigue loading, and interdigitation. Each property value was comparable to or better than that for a PMMA bone cement approved for use in BKP. Thus, the results for the composite bone cements are promising.
AB - There is a growing body of the literature on new cement formulations that address the shortcomings of PMMA bone cements approved for use in vertebroplasty (VP) and balloon kyphoplasty (BKP). The present study is a contribution to these efforts by further characterization of two pre-mixed CaP filler-reinforced PMMA bone cements intended for VP; namely, PMMA-HA and PMMA-brushite cements. Each of these cements showed acceptable levels of various properties determined in porcine vertebral bodies. These properties included radiographic contrast, maximum exotherm temperature setting time, cement extravasation, stiffness change after fatigue loading, change of VB height after fracture following fatigue loading, and interdigitation. Each property value was comparable to or better than that for a PMMA bone cement approved for use in BKP. Thus, the results for the composite bone cements are promising.
KW - Augmentation
KW - Biomechanics
KW - Composite bone cement
KW - Osseointegration
KW - Vertebroplasty
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U2 - 10.1016/j.jmbbm.2015.06.022
DO - 10.1016/j.jmbbm.2015.06.022
M3 - Article
C2 - 26177392
AN - SCOPUS:84938078748
SN - 1751-6161
VL - 50
SP - 290
EP - 298
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
ER -