Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells

Jian Xin Gao, Xingluo Liu, Jing Wen, Michael A. Caligiuri, Iwona Stroynowski, Pan Zheng, Yang Liu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Optimal activation of T cells requires delivery of both antigenic and costimulatory signals. It is unclear, however, if the function of the natural killer (NK) cells is also modulated by these 2 signals. Here we report that efficient control of solid allogeneic tumors by NK cells depends on codelivery of both B7-1 and major histocompatibility complex (MHC) class I on the tumor cells. The codelivery is required for optimal expansion and effector function of NK cells in response to both melanoma and plasmocytoma that expressed allogeneic MHC class I. Our results demonstrate that the 2 signals required for T-cell function also can regulate NK immunity and reveal an important similarity between the innate NK response and the adaptive T-cell response.

Original languageEnglish (US)
Pages (from-to)4456-4463
Number of pages8
JournalBlood
Volume102
Issue number13
DOIs
StatePublished - Dec 15 2003

Fingerprint

T-cells
Natural Killer Cells
Tumors
Chemical activation
Cells
Major Histocompatibility Complex
T-Lymphocytes
Neoplasms
Plasmacytoma
Innate Immunity
Melanoma

ASJC Scopus subject areas

  • Hematology

Cite this

Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells. / Gao, Jian Xin; Liu, Xingluo; Wen, Jing; Caligiuri, Michael A.; Stroynowski, Iwona; Zheng, Pan; Liu, Yang.

In: Blood, Vol. 102, No. 13, 15.12.2003, p. 4456-4463.

Research output: Contribution to journalArticle

Gao, Jian Xin ; Liu, Xingluo ; Wen, Jing ; Caligiuri, Michael A. ; Stroynowski, Iwona ; Zheng, Pan ; Liu, Yang. / Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells. In: Blood. 2003 ; Vol. 102, No. 13. pp. 4456-4463.
@article{4945f25100694687b82c430d3595b291,
title = "Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells",
abstract = "Optimal activation of T cells requires delivery of both antigenic and costimulatory signals. It is unclear, however, if the function of the natural killer (NK) cells is also modulated by these 2 signals. Here we report that efficient control of solid allogeneic tumors by NK cells depends on codelivery of both B7-1 and major histocompatibility complex (MHC) class I on the tumor cells. The codelivery is required for optimal expansion and effector function of NK cells in response to both melanoma and plasmocytoma that expressed allogeneic MHC class I. Our results demonstrate that the 2 signals required for T-cell function also can regulate NK immunity and reveal an important similarity between the innate NK response and the adaptive T-cell response.",
author = "Gao, {Jian Xin} and Xingluo Liu and Jing Wen and Caligiuri, {Michael A.} and Iwona Stroynowski and Pan Zheng and Yang Liu",
year = "2003",
month = "12",
day = "15",
doi = "10.1182/blood-2003-07-2480",
language = "English (US)",
volume = "102",
pages = "4456--4463",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "13",

}

TY - JOUR

T1 - Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells

AU - Gao, Jian Xin

AU - Liu, Xingluo

AU - Wen, Jing

AU - Caligiuri, Michael A.

AU - Stroynowski, Iwona

AU - Zheng, Pan

AU - Liu, Yang

PY - 2003/12/15

Y1 - 2003/12/15

N2 - Optimal activation of T cells requires delivery of both antigenic and costimulatory signals. It is unclear, however, if the function of the natural killer (NK) cells is also modulated by these 2 signals. Here we report that efficient control of solid allogeneic tumors by NK cells depends on codelivery of both B7-1 and major histocompatibility complex (MHC) class I on the tumor cells. The codelivery is required for optimal expansion and effector function of NK cells in response to both melanoma and plasmocytoma that expressed allogeneic MHC class I. Our results demonstrate that the 2 signals required for T-cell function also can regulate NK immunity and reveal an important similarity between the innate NK response and the adaptive T-cell response.

AB - Optimal activation of T cells requires delivery of both antigenic and costimulatory signals. It is unclear, however, if the function of the natural killer (NK) cells is also modulated by these 2 signals. Here we report that efficient control of solid allogeneic tumors by NK cells depends on codelivery of both B7-1 and major histocompatibility complex (MHC) class I on the tumor cells. The codelivery is required for optimal expansion and effector function of NK cells in response to both melanoma and plasmocytoma that expressed allogeneic MHC class I. Our results demonstrate that the 2 signals required for T-cell function also can regulate NK immunity and reveal an important similarity between the innate NK response and the adaptive T-cell response.

UR - http://www.scopus.com/inward/record.url?scp=0344737668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344737668&partnerID=8YFLogxK

U2 - 10.1182/blood-2003-07-2480

DO - 10.1182/blood-2003-07-2480

M3 - Article

C2 - 12933569

AN - SCOPUS:0344737668

VL - 102

SP - 4456

EP - 4463

JO - Blood

JF - Blood

SN - 0006-4971

IS - 13

ER -