Abstract
In this issue of Structure, Shang and Kojetin (2021) present insights into the binding mechanism of artificial agonists to the PPARγ nuclear receptor. These data support a two-step model with induced fit and conformational selection aspects. This mechanism may exist in related receptors, providing new opportunities for drug development.
Original language | English (US) |
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Pages (from-to) | 935-936 |
Number of pages | 2 |
Journal | Structure |
Volume | 29 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2 2021 |
Externally published | Yes |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology