Two steroid 21-hydroxylase genes are located in the murine S region

Perrin C. White, David D. Chaplin, John H. Weis, Bo Dupont, Maria I. New, J. G. Seidman

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Abstract

A common inherited disorder of steroidogenesis in man, 21-hydroxylase (21-OH) deficiency, is linked to the HLA major histocompatibility complex (MHC)1, and is associated in particular with certain allotypes of the HLA-linked complement proteins2,3. Recently, this disorder was demonstrated to result from a defective structural gene for the 21-OH enzyme, also termed cytochrome P-450C21 (ref. 4). The human (HLA) and murine (H-2) MHCs are homologous in overall organization and in the structures of their component genes5. To determine whether 21-OH genes are located in the H-2 complex, we have now used a bovine adrenal complementary DNA clone encoding part of 21-OH6 to examine a cluster of overlapping cosmid clones derived from the S region of the BALB/c mouse7. We found that there are two 21-OH genes in this region, located immediately 3′ to the C4 and Slp genes.

Original languageEnglish (US)
Pages (from-to)465-467
Number of pages3
JournalNature
Volume312
Issue number5993
DOIs
StatePublished - 1984

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    White, P. C., Chaplin, D. D., Weis, J. H., Dupont, B., New, M. I., & Seidman, J. G. (1984). Two steroid 21-hydroxylase genes are located in the murine S region. Nature, 312(5993), 465-467. https://doi.org/10.1038/312465a0