Two-, three- and four-component coupling to form isoquinolones based on directed metalation

Monika I. Antczak, Joseph M. Ready

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Benzamides undergo ortho-metalation with magnesiate bases to allow trapping with propargylic chlorides. Cyclization provides isoquinolones in a one-pot operation. Benzamides can be formed in situ from aryl Grignard reagents and isocyanates. Moreover, electrophilic trapping after cyclization introduces further complexity. Alternative cyclization conditions provide the isomeric aza-isocoumarins.

Original languageEnglish (US)
Pages (from-to)1450-1454
Number of pages5
JournalChemical Science
Volume3
Issue number5
DOIs
StatePublished - May 1 2012

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Two-, three- and four-component coupling to form isoquinolones based on directed metalation'. Together they form a unique fingerprint.

  • Cite this