Abstract
Benzamides undergo ortho-metalation with magnesiate bases to allow trapping with propargylic chlorides. Cyclization provides isoquinolones in a one-pot operation. Benzamides can be formed in situ from aryl Grignard reagents and isocyanates. Moreover, electrophilic trapping after cyclization introduces further complexity. Alternative cyclization conditions provide the isomeric aza-isocoumarins.
Original language | English (US) |
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Pages (from-to) | 1450-1454 |
Number of pages | 5 |
Journal | Chemical Science |
Volume | 3 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2012 |
ASJC Scopus subject areas
- General Chemistry