Two-, three- and four-component coupling to form isoquinolones based on directed metalation

Monika I. Antczak, Joseph M. Ready

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Benzamides undergo ortho-metalation with magnesiate bases to allow trapping with propargylic chlorides. Cyclization provides isoquinolones in a one-pot operation. Benzamides can be formed in situ from aryl Grignard reagents and isocyanates. Moreover, electrophilic trapping after cyclization introduces further complexity. Alternative cyclization conditions provide the isomeric aza-isocoumarins.

Original languageEnglish (US)
Pages (from-to)1450-1454
Number of pages5
JournalChemical Science
Volume3
Issue number5
DOIs
StatePublished - May 2012

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Cyclization
Benzamides
Isocoumarins
Isocyanates
Chlorides

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Two-, three- and four-component coupling to form isoquinolones based on directed metalation. / Antczak, Monika I.; Ready, Joseph M.

In: Chemical Science, Vol. 3, No. 5, 05.2012, p. 1450-1454.

Research output: Contribution to journalArticle

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