Two-time-point FDG PET/CT

Liver SULmeanrepeatability

Abdet K. Tahari, Vasavi Paidpally, Alin Chirindet, Richard L. Wahl, Rathan M. Subramaniam

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective. The purpose of this study was to evaluate the repeatability of liver mean standardized uptake value normalized to lean body mass (SULmean) in the same patients at different time points within the right lobe of the liver at 18F-FDG PET/CT, in a clinical setting, Materials and methods. Two PET/CT studies performed on two different dates from each of 130 patients who had normal livers according to structural imaging were included in this reader study. The mean (± SD) length of time between the studies was 235 ± 192 days. SULmean was measured with a 30-mm diameter spherical volume of interest (VOI) placed within the right lobe of the liver (above, betow, and at the levet of the main portal vein) by two expert readers. ANOVA, intraclass corretation coeflicient (ICC), and Bland-Altman analysis were performed. Results. The ICC for the first and second set of studies varied between 0.487 and 0.535 for reader 1 and between 0.472 and 0.545 for reader 2. The mean percentage variation for SULmeanbetween the two time scans for the VOls placed above, betow, and at the levet of the main portal vein were 3.55% ± 23.19%, 4.65% ± 23.87%, and 4.30% ± 23.03%, respectivety, for reader 1 and 4.49% ± 23.23%, 4.33%. ± 23.74%, and 4.48% ± 23.01%., respectivety, for reader 2. Using 95% CI, the reference range for intrapatient variations between the studies in liver SULmean was-0.5 to 0.60. Conclusion. There is only fair repeatability of liver SULmean measured between two time points in the same patient in a clinical setting. Scan-to-scan intrapatient variation in absolute liver SULmean was -0.5 to 0.60.

Original languageEnglish (US)
Pages (from-to)402-407
Number of pages6
JournalAmerican Journal of Roentgenology
Volume204
Issue number2
DOIs
StatePublished - Jan 1 2015

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Liver
Portal Vein
Fluorodeoxyglucose F18
Analysis of Variance
Reference Values

Keywords

  • Liver mean standardized uptake value (SUV) normalized to lean body mass (SUL<inf>mean</inf>)
  • PET/CT
  • Repeatability
  • Therapy assessment

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Two-time-point FDG PET/CT : Liver SULmeanrepeatability. / Tahari, Abdet K.; Paidpally, Vasavi; Chirindet, Alin; Wahl, Richard L.; Subramaniam, Rathan M.

In: American Journal of Roentgenology, Vol. 204, No. 2, 01.01.2015, p. 402-407.

Research output: Contribution to journalArticle

Tahari, Abdet K. ; Paidpally, Vasavi ; Chirindet, Alin ; Wahl, Richard L. ; Subramaniam, Rathan M. / Two-time-point FDG PET/CT : Liver SULmeanrepeatability. In: American Journal of Roentgenology. 2015 ; Vol. 204, No. 2. pp. 402-407.
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abstract = "Objective. The purpose of this study was to evaluate the repeatability of liver mean standardized uptake value normalized to lean body mass (SULmean) in the same patients at different time points within the right lobe of the liver at 18F-FDG PET/CT, in a clinical setting, Materials and methods. Two PET/CT studies performed on two different dates from each of 130 patients who had normal livers according to structural imaging were included in this reader study. The mean (± SD) length of time between the studies was 235 ± 192 days. SULmean was measured with a 30-mm diameter spherical volume of interest (VOI) placed within the right lobe of the liver (above, betow, and at the levet of the main portal vein) by two expert readers. ANOVA, intraclass corretation coeflicient (ICC), and Bland-Altman analysis were performed. Results. The ICC for the first and second set of studies varied between 0.487 and 0.535 for reader 1 and between 0.472 and 0.545 for reader 2. The mean percentage variation for SULmeanbetween the two time scans for the VOls placed above, betow, and at the levet of the main portal vein were 3.55{\%} ± 23.19{\%}, 4.65{\%} ± 23.87{\%}, and 4.30{\%} ± 23.03{\%}, respectivety, for reader 1 and 4.49{\%} ± 23.23{\%}, 4.33{\%}. ± 23.74{\%}, and 4.48{\%} ± 23.01{\%}., respectivety, for reader 2. Using 95{\%} CI, the reference range for intrapatient variations between the studies in liver SULmean was-0.5 to 0.60. Conclusion. There is only fair repeatability of liver SULmean measured between two time points in the same patient in a clinical setting. Scan-to-scan intrapatient variation in absolute liver SULmean was -0.5 to 0.60.",
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AU - Wahl, Richard L.

AU - Subramaniam, Rathan M.

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N2 - Objective. The purpose of this study was to evaluate the repeatability of liver mean standardized uptake value normalized to lean body mass (SULmean) in the same patients at different time points within the right lobe of the liver at 18F-FDG PET/CT, in a clinical setting, Materials and methods. Two PET/CT studies performed on two different dates from each of 130 patients who had normal livers according to structural imaging were included in this reader study. The mean (± SD) length of time between the studies was 235 ± 192 days. SULmean was measured with a 30-mm diameter spherical volume of interest (VOI) placed within the right lobe of the liver (above, betow, and at the levet of the main portal vein) by two expert readers. ANOVA, intraclass corretation coeflicient (ICC), and Bland-Altman analysis were performed. Results. The ICC for the first and second set of studies varied between 0.487 and 0.535 for reader 1 and between 0.472 and 0.545 for reader 2. The mean percentage variation for SULmeanbetween the two time scans for the VOls placed above, betow, and at the levet of the main portal vein were 3.55% ± 23.19%, 4.65% ± 23.87%, and 4.30% ± 23.03%, respectivety, for reader 1 and 4.49% ± 23.23%, 4.33%. ± 23.74%, and 4.48% ± 23.01%., respectivety, for reader 2. Using 95% CI, the reference range for intrapatient variations between the studies in liver SULmean was-0.5 to 0.60. Conclusion. There is only fair repeatability of liver SULmean measured between two time points in the same patient in a clinical setting. Scan-to-scan intrapatient variation in absolute liver SULmean was -0.5 to 0.60.

AB - Objective. The purpose of this study was to evaluate the repeatability of liver mean standardized uptake value normalized to lean body mass (SULmean) in the same patients at different time points within the right lobe of the liver at 18F-FDG PET/CT, in a clinical setting, Materials and methods. Two PET/CT studies performed on two different dates from each of 130 patients who had normal livers according to structural imaging were included in this reader study. The mean (± SD) length of time between the studies was 235 ± 192 days. SULmean was measured with a 30-mm diameter spherical volume of interest (VOI) placed within the right lobe of the liver (above, betow, and at the levet of the main portal vein) by two expert readers. ANOVA, intraclass corretation coeflicient (ICC), and Bland-Altman analysis were performed. Results. The ICC for the first and second set of studies varied between 0.487 and 0.535 for reader 1 and between 0.472 and 0.545 for reader 2. The mean percentage variation for SULmeanbetween the two time scans for the VOls placed above, betow, and at the levet of the main portal vein were 3.55% ± 23.19%, 4.65% ± 23.87%, and 4.30% ± 23.03%, respectivety, for reader 1 and 4.49% ± 23.23%, 4.33%. ± 23.74%, and 4.48% ± 23.01%., respectivety, for reader 2. Using 95% CI, the reference range for intrapatient variations between the studies in liver SULmean was-0.5 to 0.60. Conclusion. There is only fair repeatability of liver SULmean measured between two time points in the same patient in a clinical setting. Scan-to-scan intrapatient variation in absolute liver SULmean was -0.5 to 0.60.

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KW - PET/CT

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KW - Therapy assessment

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