Two Zinc Finger Proteins, OMA-1 and OMA-2, Are Redundantly Required for Oocyte Maturation in C. elegans

Michelle R. Detwiler, Melanie Reuben, Xiumin Li, Eric Rogers, Rueyling Lin

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Oocytes are released from meiotic prophase I arrest through a process termed oocyte maturation. We present here a genetic characterization of oocyte maturation, using C. elegans as a model system. We show that two TIS11 zinc finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing oocytes and function redundantly in oocyte maturation. Oocytes in oma-1;oma-2 mutants initiate but do not complete maturation and arrest at a defined point in prophase I. Two maturation signal-induced molecular events, including the maintenance of activated MAP kinase, do not occur in Oma oocytes. The Oma prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of prophase progression during meiotic maturation.

Original languageEnglish (US)
Pages (from-to)187-199
Number of pages13
JournalDevelopmental Cell
Volume1
Issue number2
DOIs
StatePublished - Aug 2001

Fingerprint

Zinc Fingers
Oocytes
Zinc
Phosphotransferases
Proteins
Meiotic Prophase I
Prophase
Maintenance

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Two Zinc Finger Proteins, OMA-1 and OMA-2, Are Redundantly Required for Oocyte Maturation in C. elegans. / Detwiler, Michelle R.; Reuben, Melanie; Li, Xiumin; Rogers, Eric; Lin, Rueyling.

In: Developmental Cell, Vol. 1, No. 2, 08.2001, p. 187-199.

Research output: Contribution to journalArticle

Detwiler, Michelle R. ; Reuben, Melanie ; Li, Xiumin ; Rogers, Eric ; Lin, Rueyling. / Two Zinc Finger Proteins, OMA-1 and OMA-2, Are Redundantly Required for Oocyte Maturation in C. elegans. In: Developmental Cell. 2001 ; Vol. 1, No. 2. pp. 187-199.
@article{2ee65a69f9d6429a9c05a776c92c99ea,
title = "Two Zinc Finger Proteins, OMA-1 and OMA-2, Are Redundantly Required for Oocyte Maturation in C. elegans",
abstract = "Oocytes are released from meiotic prophase I arrest through a process termed oocyte maturation. We present here a genetic characterization of oocyte maturation, using C. elegans as a model system. We show that two TIS11 zinc finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing oocytes and function redundantly in oocyte maturation. Oocytes in oma-1;oma-2 mutants initiate but do not complete maturation and arrest at a defined point in prophase I. Two maturation signal-induced molecular events, including the maintenance of activated MAP kinase, do not occur in Oma oocytes. The Oma prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of prophase progression during meiotic maturation.",
author = "Detwiler, {Michelle R.} and Melanie Reuben and Xiumin Li and Eric Rogers and Rueyling Lin",
year = "2001",
month = "8",
doi = "10.1016/S1534-5807(01)00026-0",
language = "English (US)",
volume = "1",
pages = "187--199",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "2",

}

TY - JOUR

T1 - Two Zinc Finger Proteins, OMA-1 and OMA-2, Are Redundantly Required for Oocyte Maturation in C. elegans

AU - Detwiler, Michelle R.

AU - Reuben, Melanie

AU - Li, Xiumin

AU - Rogers, Eric

AU - Lin, Rueyling

PY - 2001/8

Y1 - 2001/8

N2 - Oocytes are released from meiotic prophase I arrest through a process termed oocyte maturation. We present here a genetic characterization of oocyte maturation, using C. elegans as a model system. We show that two TIS11 zinc finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing oocytes and function redundantly in oocyte maturation. Oocytes in oma-1;oma-2 mutants initiate but do not complete maturation and arrest at a defined point in prophase I. Two maturation signal-induced molecular events, including the maintenance of activated MAP kinase, do not occur in Oma oocytes. The Oma prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of prophase progression during meiotic maturation.

AB - Oocytes are released from meiotic prophase I arrest through a process termed oocyte maturation. We present here a genetic characterization of oocyte maturation, using C. elegans as a model system. We show that two TIS11 zinc finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing oocytes and function redundantly in oocyte maturation. Oocytes in oma-1;oma-2 mutants initiate but do not complete maturation and arrest at a defined point in prophase I. Two maturation signal-induced molecular events, including the maintenance of activated MAP kinase, do not occur in Oma oocytes. The Oma prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of prophase progression during meiotic maturation.

UR - http://www.scopus.com/inward/record.url?scp=0035433726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035433726&partnerID=8YFLogxK

U2 - 10.1016/S1534-5807(01)00026-0

DO - 10.1016/S1534-5807(01)00026-0

M3 - Article

C2 - 11702779

AN - SCOPUS:0035433726

VL - 1

SP - 187

EP - 199

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 2

ER -