@article{2ee65a69f9d6429a9c05a776c92c99ea,
title = "Two Zinc Finger Proteins, OMA-1 and OMA-2, Are Redundantly Required for Oocyte Maturation in C. elegans",
abstract = "Oocytes are released from meiotic prophase I arrest through a process termed oocyte maturation. We present here a genetic characterization of oocyte maturation, using C. elegans as a model system. We show that two TIS11 zinc finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing oocytes and function redundantly in oocyte maturation. Oocytes in oma-1;oma-2 mutants initiate but do not complete maturation and arrest at a defined point in prophase I. Two maturation signal-induced molecular events, including the maintenance of activated MAP kinase, do not occur in Oma oocytes. The Oma prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of prophase progression during meiotic maturation.",
author = "Detwiler, {Michelle R.} and Melanie Reuben and Xiumin Li and Eric Rogers and Rueyling Lin",
note = "Funding Information: The authors thank T. Schedl, A. Golden, E. Olson, and J. Waddle for critical reading of the manuscript. Special thanks are given to Scott Robertson for his time and efforts in reading and editing the manuscript. We would also like to thank Jill Schumacher for the AIR-2 antibody, Yosef Gruenbaum for the lamin antibody, Kathy Wilson for the Ce-emerin antibody, David Allis for the H3P antibody, Judith Austin for the H2B-GFP strain, Tim Schedl, Mary Kosinski, and Andy Golden for sharing reagents and unpublished results, Yuji Kohara for yk89e11 and yk14f9, and Jim Priess for the mAB414, MEX-1, MEX-5, and SKN-1 antibodies. The authors also thank Alan Coulson for all C. elegans cosmids used in this study. Unless mentioned otherwise, all strains used in this study were provided by the C. elegans Genome Consortium (CGC). This research was supported by a grant from NIH to R.L. (HD37933).",
year = "2001",
month = aug,
doi = "10.1016/S1534-5807(01)00026-0",
language = "English (US)",
volume = "1",
pages = "187--199",
journal = "Developmental cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "2",
}