Twofold unsymmetrical C-H functionalization of PyrDipSi-substituted arenes: A general method for the synthesis of substituted meta-halophenols

Dhruba Sarkar, Ferdinand S. Melkonyan, Anton V. Gulevich, Vladimir Gevorgyan

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

And the world is your oyster Sequential halogenation/oxygenation reactions of 2-diisopropylsilylpyrimidine-substituted arenes provide a general and efficient synthesis of substituted meta-halophenols from simple aryl iodides (see scheme; Piv=pivaloyl). The products are poised to undergo diverse C-C, C-N, and C-O bond-forming reactions that enable the transformation of their framework and the introduction of valuable functionalities.

Original languageEnglish (US)
Pages (from-to)10800-10804
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number41
DOIs
StatePublished - Oct 4 2013
Externally publishedYes

Keywords

  • C-H activation
  • cross-coupling
  • halogenation
  • oxygenation
  • palladium

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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