Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis

Cong Wang, Julia Yu Fong Chang, Chaofeng Yang, Yanqing Huang, Junchen Liu, Pan You, Wallace L. McKeehan, Fen Wang, Xiaokun Li

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Background: How Fgfr1 mutations cause cleft palate is unclear. Results: Deleting Fgfr1 in neural crest cells caused defects in both palate shelf epithelium and mesenchyme and led to cleft palate. Conclusion: FGFR1 signaling in cranial neural crest (CNC) cells regulates palate shelf growth and fusion during palatogenesis. Significance: The finding for the first time demonstrates how FGF signaling in CNC cells regulates palatogenesis.

Original languageEnglish (US)
Pages (from-to)22174-22183
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number30
DOIs
StatePublished - Jul 26 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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