Type I interferon response and innate immune sensing of cancer

Mercedes B. Fuertes, Seng Ryong Woo, Byron Burnett, Yang Xin Fu, Thomas F. Gajewski

Research output: Contribution to journalReview article

137 Scopus citations

Abstract

Unexpectedly, many cancers appear to induce a spontaneous adaptive T cell response. The presence of a T cell infiltrate has been linked to favorable clinical outcome in multiple cancer types. However, the innate immune pathways that bridge to an adaptive immune response under sterile conditions are poorly understood. Recent data have indicated that tumors can induce type I interferon (IFN) production by host antigen-presenting cells (APCs), which is required for a spontaneous T cell response in vivo. The innate immune sensing pathways that trigger type I IFN production are being elucidated. Host type I IFNs are also required for optimal therapeutic efficacy with radiation. This recently uncovered role for host type I IFNs for antitumor immunity has important fundamental and clinical implications.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalTrends in Immunology
Volume34
Issue number2
DOIs
StatePublished - Feb 1 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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