Type I interferons (α/β) in immunity and autoimmunity

Argyrios N. Theofilopoulos, Roberto Baccala, Bruce Beutler, Dwight H. Kono

Research output: Contribution to journalReview article

919 Scopus citations

Abstract

The significance of type I interferons (IFN-α/β) in biology and medicine renders research on their activities continuously relevant to our understanding of normal and abnormal (auto) immune responses. This relevance is bolstered by discoveries that unambiguously establish IFN-α/β, among the multitude of cytokines, as dominant in defining qualitative and quantitative characteristics of innate and adaptive immune processes. Recent advances elucidating the biology of these key cytokines include better definition of their complex signaling pathways, determination of their importance in modifying the effects of other cytokines, the role of Toll-like receptors in their induction, their major cellular producers, and their broad and diverse impact on both cellular and humoral immune responses. Consequently, the role of IFN-α/β in the pathogenesis of autoimmunity remains at the forefront of scientific inquiry and has begun to illuminate the mechanisms by which these molecules promote or inhibit systemic and organ-specific autoimmune diseases. 307-336

Original languageEnglish (US)
Pages (from-to)307-336
Number of pages30
JournalAnnual review of immunology
Volume23
DOIs
StatePublished - May 5 2005

Keywords

  • IDDM
  • Innate immunity
  • Lupus
  • Plasmacytoid cells
  • TLR

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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