Abstract
The significance of type I interferons (IFN-α/β) in biology and medicine renders research on their activities continuously relevant to our understanding of normal and abnormal (auto) immune responses. This relevance is bolstered by discoveries that unambiguously establish IFN-α/β, among the multitude of cytokines, as dominant in defining qualitative and quantitative characteristics of innate and adaptive immune processes. Recent advances elucidating the biology of these key cytokines include better definition of their complex signaling pathways, determination of their importance in modifying the effects of other cytokines, the role of Toll-like receptors in their induction, their major cellular producers, and their broad and diverse impact on both cellular and humoral immune responses. Consequently, the role of IFN-α/β in the pathogenesis of autoimmunity remains at the forefront of scientific inquiry and has begun to illuminate the mechanisms by which these molecules promote or inhibit systemic and organ-specific autoimmune diseases. 307-336
| Original language | English (US) |
|---|---|
| Pages (from-to) | 307-336 |
| Number of pages | 30 |
| Journal | Annual Review of Immunology |
| Volume | 23 |
| DOIs | |
| State | Published - 2005 |
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Keywords
- IDDM
- Innate immunity
- Lupus
- Plasmacytoid cells
- TLR
ASJC Scopus subject areas
- Immunology
Cite this
Type I interferons (α/β) in immunity and autoimmunity. / Theofilopoulos, Argyrios N.; Baccala, Roberto; Beutler, Bruce; Kono, Dwight H.
In: Annual Review of Immunology, Vol. 23, 2005, p. 307-336.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Type I interferons (α/β) in immunity and autoimmunity
AU - Theofilopoulos, Argyrios N.
AU - Baccala, Roberto
AU - Beutler, Bruce
AU - Kono, Dwight H.
PY - 2005
Y1 - 2005
N2 - The significance of type I interferons (IFN-α/β) in biology and medicine renders research on their activities continuously relevant to our understanding of normal and abnormal (auto) immune responses. This relevance is bolstered by discoveries that unambiguously establish IFN-α/β, among the multitude of cytokines, as dominant in defining qualitative and quantitative characteristics of innate and adaptive immune processes. Recent advances elucidating the biology of these key cytokines include better definition of their complex signaling pathways, determination of their importance in modifying the effects of other cytokines, the role of Toll-like receptors in their induction, their major cellular producers, and their broad and diverse impact on both cellular and humoral immune responses. Consequently, the role of IFN-α/β in the pathogenesis of autoimmunity remains at the forefront of scientific inquiry and has begun to illuminate the mechanisms by which these molecules promote or inhibit systemic and organ-specific autoimmune diseases. 307-336
AB - The significance of type I interferons (IFN-α/β) in biology and medicine renders research on their activities continuously relevant to our understanding of normal and abnormal (auto) immune responses. This relevance is bolstered by discoveries that unambiguously establish IFN-α/β, among the multitude of cytokines, as dominant in defining qualitative and quantitative characteristics of innate and adaptive immune processes. Recent advances elucidating the biology of these key cytokines include better definition of their complex signaling pathways, determination of their importance in modifying the effects of other cytokines, the role of Toll-like receptors in their induction, their major cellular producers, and their broad and diverse impact on both cellular and humoral immune responses. Consequently, the role of IFN-α/β in the pathogenesis of autoimmunity remains at the forefront of scientific inquiry and has begun to illuminate the mechanisms by which these molecules promote or inhibit systemic and organ-specific autoimmune diseases. 307-336
KW - IDDM
KW - Innate immunity
KW - Lupus
KW - Plasmacytoid cells
KW - TLR
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UR - http://www.scopus.com/inward/citedby.url?scp=17644402442&partnerID=8YFLogxK
U2 - 10.1146/annurev.immunol.23.021704.115843
DO - 10.1146/annurev.immunol.23.021704.115843
M3 - Article
C2 - 15771573
AN - SCOPUS:17644402442
VL - 23
SP - 307
EP - 336
JO - Annual Review of Immunology
JF - Annual Review of Immunology
SN - 0732-0582
ER -