Type II CAAX prenyl endopeptidases belong to a novel superfamily of putative membrane-bound metalloproteases

Jimin Pei, Nick V. Grishin

Research output: Contribution to journalShort surveypeer-review

98 Scopus citations

Abstract

In this article, a novel, large and diverse superfamily of putative membrane-bound proteins that includes the type II CAAX prenyl endopeptidases is described. The majority of the members of this superfamily are hypothetical proteins from bacteria and plants. Analysis of the conserved motifs, combined with available experimental data, suggests that these proteins are putative metal-dependent proteases that are potentially involved in protein and/or peptide modification and secretion.

Original languageEnglish (US)
Pages (from-to)275-277
Number of pages3
JournalTrends in Biochemical Sciences
Volume26
Issue number5
DOIs
StatePublished - May 1 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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