Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis

Young Gyu Cho, Mi La Cho, So Youn Min, Ho Youn Kim

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long time, definitive conclusions have not been reached. CII, as an autoantigen, has been studied extensively in small animal models, such as mice, and the collagen-induced arthritis (CIA) model has increased our understanding of the pathogenesis of human RA. In the present report, we summarize the available information on anti-CII immunity and discuss recent updates regarding pathogenesis in the CIA model, including the role of Th17 cells.

Original languageEnglish (US)
Pages (from-to)65-70
Number of pages6
JournalAutoimmunity Reviews
Volume7
Issue number1
DOIs
StatePublished - Nov 2007

Fingerprint

Experimental Arthritis
Collagen Type II
Autoimmunity
Immunity
Rheumatoid Arthritis
Joints
Th17 Cells
Autoantigens
Animal Models

Keywords

  • Collagen-induced arthritis (CIA)
  • IL-17
  • Rheumatoid arthritis (RA)
  • Toll-like receptor (TLR)

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis. / Cho, Young Gyu; Cho, Mi La; Min, So Youn; Kim, Ho Youn.

In: Autoimmunity Reviews, Vol. 7, No. 1, 11.2007, p. 65-70.

Research output: Contribution to journalArticle

Cho, Young Gyu ; Cho, Mi La ; Min, So Youn ; Kim, Ho Youn. / Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis. In: Autoimmunity Reviews. 2007 ; Vol. 7, No. 1. pp. 65-70.
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