Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis

Young Gyu Cho, Mi La Cho, So Youn Min, Ho Youn Kim

Research output: Contribution to journalReview articlepeer-review

160 Scopus citations

Abstract

Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long time, definitive conclusions have not been reached. CII, as an autoantigen, has been studied extensively in small animal models, such as mice, and the collagen-induced arthritis (CIA) model has increased our understanding of the pathogenesis of human RA. In the present report, we summarize the available information on anti-CII immunity and discuss recent updates regarding pathogenesis in the CIA model, including the role of Th17 cells.

Original languageEnglish (US)
Pages (from-to)65-70
Number of pages6
JournalAutoimmunity Reviews
Volume7
Issue number1
DOIs
StatePublished - Nov 1 2007

Keywords

  • Collagen-induced arthritis (CIA)
  • IL-17
  • Rheumatoid arthritis (RA)
  • Toll-like receptor (TLR)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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