Tyrosine kinases in inflammatory dermatologic disease

Ricardo T. Paniagua, David F. Fiorentino, Lorinda Chung, William H. Robinson

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Tyrosine kinases (TKs) are enzymes that catalyze the phosphorylation of tyrosine residues on protein substrates. They are key components of signaling pathways that drive an array of cellular responses including proliferation, differentiation, migration, and survival. Specific TKs have recently been identified as critical to the pathogenesis of several autoimmune and inflammatory diseases. Small-molecule inhibitors of TKs are emerging as a novel class of therapy that may provide benefit in certain patient subsets. In this review, we highlight TK signaling implicated in inflammatory dermatologic diseases, evaluate strategies aimed at inhibiting these aberrant signaling pathways, and discuss prospects for future drug development.

Original languageEnglish (US)
Pages (from-to)389-403
Number of pages15
JournalJournal of the American Academy of Dermatology
Volume65
Issue number2
DOIs
StatePublished - Aug 2011

Keywords

  • autoimmune
  • dermatology
  • dermatomyositis
  • fibrosis
  • inflammatory
  • pemphigus
  • phosphorylation
  • psoriasis
  • tyrosine kinase

ASJC Scopus subject areas

  • Dermatology

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