TY - JOUR
T1 - U-47700
T2 - A Clinical Review of the Literature
AU - Rambaran, Kerry Anne
AU - Fleming, Steven W.
AU - An, Jie
AU - Burkhart, Samantha
AU - Furmaga, Jakub
AU - Kleinschmidt, Kurt C.
AU - Spiekerman, Michael A.
AU - Alzghari, Saeed K.
PY - 2017
Y1 - 2017
N2 - Background: U-47700 is a synthetic opioid developed by The Upjohn Company in the 1970s, which has recently appeared in the news and medical literature due to its toxicity. Currently, there are no clinical trial data assessing the safety of U-47700. Objective: To describe the signs and symptoms of ingestion, laboratory testing, and treatment modalities for U-47700 intoxication. Discussion: We searched PubMed, Embase, Web of Science, and EBSCO for articles using the term "U-47700" and "47700." The following inclusion criteria were used: had to be in English; full text; must involve humans; must be either a randomized control trial, prospective trial, retrospective analysis, case series, or case report; and must include clinical findings at presentation. We identified and extracted data from relevant articles. Ten relevant articles were included with 16 patients. Patients that died after overdose with U-47700 typically presented to the hospital with pulmonary edema. Patients who survived an overdose presented with decreased mental status and decreased respiratory rate suggestive of an opioid toxidrome. Patients also commonly had tachycardia. Immunoassays failed to identify U-47700, and the identification of U-47700 required the use of chromatographic and spectral techniques. Conclusion: We report the first clinical review of U-47700 intoxication.
AB - Background: U-47700 is a synthetic opioid developed by The Upjohn Company in the 1970s, which has recently appeared in the news and medical literature due to its toxicity. Currently, there are no clinical trial data assessing the safety of U-47700. Objective: To describe the signs and symptoms of ingestion, laboratory testing, and treatment modalities for U-47700 intoxication. Discussion: We searched PubMed, Embase, Web of Science, and EBSCO for articles using the term "U-47700" and "47700." The following inclusion criteria were used: had to be in English; full text; must involve humans; must be either a randomized control trial, prospective trial, retrospective analysis, case series, or case report; and must include clinical findings at presentation. We identified and extracted data from relevant articles. Ten relevant articles were included with 16 patients. Patients that died after overdose with U-47700 typically presented to the hospital with pulmonary edema. Patients who survived an overdose presented with decreased mental status and decreased respiratory rate suggestive of an opioid toxidrome. Patients also commonly had tachycardia. Immunoassays failed to identify U-47700, and the identification of U-47700 required the use of chromatographic and spectral techniques. Conclusion: We report the first clinical review of U-47700 intoxication.
KW - Drugs of abuse
KW - Novel psychoactive substance
KW - Opioid poisoning
KW - Opioid toxidrome
KW - Overdose
KW - Synthetic opioid
KW - U-47700
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U2 - 10.1016/j.jemermed.2017.05.034
DO - 10.1016/j.jemermed.2017.05.034
M3 - Article
C2 - 28911989
AN - SCOPUS:85028987058
SN - 0736-4679
JO - Journal of Emergency Medicine
JF - Journal of Emergency Medicine
ER -