Ubiquitin-dependent activation of NF-κB: K63-linked ubiquitin chains - A link to cancer?

Zhijian J. Chen; Serge Y. Fuchs

Ubiquitin-dependent activation of NF-κB: K63-linked ubiquitin chains - A link to cancer?

Research output: Contribution to journal › Review article › peer-review

Abstract

Recent discoveries of the novel roles of lysine 63-linked polyubiquitin chains in the activation of NF-κB transcription factor shed new light on both the mechanistic aspects of this signal transduction pathway and its role in cancer.

Original language	English (US)
Pages (from-to)	e67-e69
Journal	Cancer Biology and Therapy
Volume	3
Issue number	3
State	Published - Mar 1 2004

Keywords

CYLD
Cancer
E3 ligase
IKK
IκB
Kinase
NF-κB
Nemo
Ubiquitin

ASJC Scopus subject areas

Molecular Medicine
Oncology
Pharmacology
Cancer Research

Cite this

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title = "Ubiquitin-dependent activation of NF-κB: K63-linked ubiquitin chains - A link to cancer?",

abstract = "Recent discoveries of the novel roles of lysine 63-linked polyubiquitin chains in the activation of NF-κB transcription factor shed new light on both the mechanistic aspects of this signal transduction pathway and its role in cancer.",

keywords = "CYLD, Cancer, E3 ligase, IKK, IκB, Kinase, NF-κB, Nemo, Ubiquitin",

author = "Chen, {Zhijian J.} and Fuchs, {Serge Y.}",

year = "2004",

month = mar,

day = "1",

language = "English (US)",

volume = "3",

pages = "e67--e69",

journal = "Cancer Biology and Therapy",

issn = "1538-4047",

publisher = "Landes Bioscience",

number = "3",

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TY - JOUR

T1 - Ubiquitin-dependent activation of NF-κB

T2 - K63-linked ubiquitin chains - A link to cancer?

AU - Chen, Zhijian J.

AU - Fuchs, Serge Y.

PY - 2004/3/1

Y1 - 2004/3/1

N2 - Recent discoveries of the novel roles of lysine 63-linked polyubiquitin chains in the activation of NF-κB transcription factor shed new light on both the mechanistic aspects of this signal transduction pathway and its role in cancer.

AB - Recent discoveries of the novel roles of lysine 63-linked polyubiquitin chains in the activation of NF-κB transcription factor shed new light on both the mechanistic aspects of this signal transduction pathway and its role in cancer.

KW - CYLD

KW - Cancer

KW - E3 ligase

KW - IKK

KW - IκB

KW - Kinase

KW - NF-κB

KW - Nemo

KW - Ubiquitin

UR - http://www.scopus.com/inward/record.url?scp=25144438691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25144438691&partnerID=8YFLogxK

M3 - Review article

C2 - 15004521

AN - SCOPUS:25144438691

SN - 1538-4047

VL - 3

SP - e67-e69

JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

IS - 3

ER -

Ubiquitin-dependent activation of NF-κB: K63-linked ubiquitin chains - A link to cancer?

Abstract

Keywords

ASJC Scopus subject areas

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