Ubiquitin-dependent activation of NF-κB: K63-linked ubiquitin chains - A link to cancer?

Zhijian J. Chen, Serge Y. Fuchs

Research output: Contribution to journalReview article

10 Scopus citations


Recent discoveries of the novel roles of lysine 63-linked polyubiquitin chains in the activation of NF-κB transcription factor shed new light on both the mechanistic aspects of this signal transduction pathway and its role in cancer.

Original languageEnglish (US)
Pages (from-to)e67-e69
JournalCancer Biology and Therapy
Issue number3
StatePublished - Mar 1 2004



  • CYLD
  • Cancer
  • E3 ligase
  • IKK
  • IκB
  • Kinase
  • NF-κB
  • Nemo
  • Ubiquitin

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

Cite this