Ubiquitin in NF-κB signaling

Yu Hsin Chiu, Meng Zhao, Zhijian J. Chen

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A study was conducted to understand the three steps of the NF-κB pathway, IκB degradation, processing of NF-κB precursors, and activation of IKK and other kinases. The study also highlighted how deubiquitination enzymes negatively regulate the NF-κB pathway and how dysfunction of these enzymes lead to human diseases. It was observed that NF-κB pathway provided an understanding of roles of ubiquitin in cell signaling including signal-dependent degradation of an inhibitor that further lead to a rapid activation of a signaling cascade, limited proteolysis of a precursor protein by the proteasome, and activation of protein kinases. The ubiquitin system played a significant role in diverse signaling cascades leading to NF-κB activation. The study also concluded that pervasive role of ubiquitin in NF-κB pathways showed the regulatory potential of ubiquitination and deubiquitination.

Original languageEnglish (US)
Pages (from-to)1549-1560
Number of pages12
JournalChemical Reviews
Volume109
Issue number4
DOIs
StatePublished - Apr 8 2009

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Ubiquitin
Chemical activation
Proteolysis
Cell signaling
Degradation
Protein Precursors
Corrosion inhibitors
Proteasome Endopeptidase Complex
Enzymes
Protein Kinases
Phosphotransferases
Processing

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Ubiquitin in NF-κB signaling. / Chiu, Yu Hsin; Zhao, Meng; Chen, Zhijian J.

In: Chemical Reviews, Vol. 109, No. 4, 08.04.2009, p. 1549-1560.

Research output: Contribution to journalArticle

Chiu, YH, Zhao, M & Chen, ZJ 2009, 'Ubiquitin in NF-κB signaling', Chemical Reviews, vol. 109, no. 4, pp. 1549-1560. https://doi.org/10.1021/cr800554j
Chiu, Yu Hsin ; Zhao, Meng ; Chen, Zhijian J. / Ubiquitin in NF-κB signaling. In: Chemical Reviews. 2009 ; Vol. 109, No. 4. pp. 1549-1560.
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