Abstract
Background: Tollip participates in endosomal membrane trafficking and innate immune pathways. Results: Ubiquitin inhibits binding of Tollip to phosphatidylinositol 3-phosphate by association to the Tollip C2 and CUE domains and dissociates Tollip CUE domain dimers. Conclusion: Ubiquitin negatively modulates membrane association of Tollip. Significance: Ubiquitin dual binding can partition Tollip into membrane-bound and cytosolic intracellular pools.
Original language | English (US) |
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Pages (from-to) | 25780-25791 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 36 |
DOIs | |
State | Published - Sep 6 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology