Ubiquitin interacts with the tollip C2 and CUE domains and inhibits binding of tollip to phosphoinositides

Sharmistha Mitra, C. Alicia Traughber, Mary K. Brannon, Stephanie Gomez, Daniel G.S. Capelluto

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Background: Tollip participates in endosomal membrane trafficking and innate immune pathways. Results: Ubiquitin inhibits binding of Tollip to phosphatidylinositol 3-phosphate by association to the Tollip C2 and CUE domains and dissociates Tollip CUE domain dimers. Conclusion: Ubiquitin negatively modulates membrane association of Tollip. Significance: Ubiquitin dual binding can partition Tollip into membrane-bound and cytosolic intracellular pools.

Original languageEnglish (US)
Pages (from-to)25780-25791
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number36
DOIs
StatePublished - Sep 6 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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