Abstract
The transcription factor NF-κB (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates at least three steps in the NF-κB pathway: degradation of IκB (inhibitor of NF-κB), processing of NF-κB precursors, and activation of the IκB kinase (IKK). Recent studies have revealed several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism.
Original language | English (US) |
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Pages (from-to) | 758-765 |
Number of pages | 8 |
Journal | Nature cell biology |
Volume | 7 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2005 |
ASJC Scopus subject areas
- Cell Biology