Ubiquitylation in innate and adaptive immunity

Vijay G. Bhoj, Zhijian J. Chen

Research output: Contribution to journalArticle

377 Citations (Scopus)

Abstract

Protein ubiquitylation has emerged as a key mechanism that regulates immune responses. Much like phosphorylation, ubiquitylation is a reversible covalent modification that regulates the stability, activity and localization of target proteins. As such, ubiquitylation regulates the development of the immune system and many phases of the immune response, including its initiation, propagation and termination. Recent work has shown that several ubiquitin ligases help to prevent the immune system from attacking self tissues. The dysfunction of several ubiquitin ligases has been linked to autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)430-437
Number of pages8
JournalNature
Volume458
Issue number7237
DOIs
StatePublished - Mar 26 2009

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Ubiquitination
Adaptive Immunity
Innate Immunity
Ligases
Ubiquitin
Immune System
Autoimmune Diseases
Proteins
Phosphorylation

ASJC Scopus subject areas

  • General

Cite this

Ubiquitylation in innate and adaptive immunity. / Bhoj, Vijay G.; Chen, Zhijian J.

In: Nature, Vol. 458, No. 7237, 26.03.2009, p. 430-437.

Research output: Contribution to journalArticle

Bhoj, Vijay G. ; Chen, Zhijian J. / Ubiquitylation in innate and adaptive immunity. In: Nature. 2009 ; Vol. 458, No. 7237. pp. 430-437.
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