ULK1 targets Beclin-1 in autophagy

Volodymyr Y. Nazarko, Qing Zhong

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been identified as a physiological substrate of the ULK kinases in autophagy following amino acid starvation, therefore suggesting a critical molecular link between the upstream kinases and the autophagy core machinery.

Original languageEnglish (US)
Pages (from-to)727-728
Number of pages2
JournalNature Cell Biology
Volume15
Issue number7
DOIs
StatePublished - Jul 2013

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Autophagy
Class III Phosphatidylinositol 3-Kinases
Phosphotransferases
Starvation
Yeasts
Amino Acids
Beclin-1

ASJC Scopus subject areas

  • Cell Biology

Cite this

ULK1 targets Beclin-1 in autophagy. / Nazarko, Volodymyr Y.; Zhong, Qing.

In: Nature Cell Biology, Vol. 15, No. 7, 07.2013, p. 727-728.

Research output: Contribution to journalArticle

Nazarko, Volodymyr Y. ; Zhong, Qing. / ULK1 targets Beclin-1 in autophagy. In: Nature Cell Biology. 2013 ; Vol. 15, No. 7. pp. 727-728.
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