Ultra-sensitive optical coherence elastography using a high-dynamic-range force loading scheme for cervical rigidity assessment

Xinwen Yao, Dawei Li, Hyeon Cheol Park, Defu Chen, Honghua Guan, Mala Mahendroo, Xingde Li

Research output: Contribution to journalArticle

Abstract

An ultra-sensitive, wide-range force loading scheme is proposed for compression optical coherence elastography (OCE) that allows for the quantitative analysis of cervical tissue elasticity ex vivo. We designed a force loading apparatus featuring a water sink for minuscule incremental loading through a volume-controlled water droplet, from which the Young’s modulus can be calculated by fitting the stress-strain curve. We validated the performance of the proposed OCE system on homogenous agar phantoms, showing the Young’s modulus can be accurately estimated using this scheme. We then measured the Young’s modulus of rodent cervical tissues acquired at different gestational ages, showing that the cervical rigidity of rodents was significantly dropped when entering the third trimester of pregnancy.

Original languageEnglish (US)
Pages (from-to)688-698
Number of pages11
JournalBiomedical Optics Express
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2020

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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