TY - JOUR
T1 - Ultrasonic enhancement of myocardial infarction with perfluorocarbon compounds in dogs
AU - Mattrey, Robert F.
AU - Andre, Michael P.
N1 - Funding Information:
From the Department of Radiology, School of Medicine, University of California, San Diego, California. This study was supported in part by the Alpha Therapeutic Corporation, Los Angeles, California; Technicare Corporation, Denver, Colorado; and Grant #1-ROl-CA36799-01 from the National Institutes of Health, Bethesda, Maryland. Manuscript received February 6, 1984; revised manuscript received February 27, 1984, accepted February 29, 1984.
PY - 1984/7/1
Y1 - 1984/7/1
N2 - Fluosol-DA 20%® (Fluosol) and perfluoroctyl-bromide (PFOB), 2 types of perfluorocarbon emulsions (PFCs), were evaluated as sound contrast agents in imaging acute myocardial infarction (Ml) in dogs. Operative ligation of a coronary artery was performed in 9 dogs. PFC was administered 2 days after occlusion. One dog received Fluosol, 10 ml/kg body weight, 2 dogs received 20 ml/kg, and 2 received 25 ml/kg; 2 dogs received PFOB, 20 ml/kg, and 2 dogs received 25 ml/kg. Just before and 2 days after PFC administration, real-time, 2-dimensional ultrasound examination of the heart was performed in the short-axis view from apex to base. No enhancement was seen at the 10-ml/kg dose, but significant mild echogenic enhancement of all MIs occurred after 20 ml/kg. Moderate to marked enhancement was noted after 25 ml/kg. The enhancement was either diffuse throughout the Ml or localized to the rim. Initial studies suggest that the mechanism of enhancement is related, at least in part, to the accumulation of RFC-filled macrophages within the MI.
AB - Fluosol-DA 20%® (Fluosol) and perfluoroctyl-bromide (PFOB), 2 types of perfluorocarbon emulsions (PFCs), were evaluated as sound contrast agents in imaging acute myocardial infarction (Ml) in dogs. Operative ligation of a coronary artery was performed in 9 dogs. PFC was administered 2 days after occlusion. One dog received Fluosol, 10 ml/kg body weight, 2 dogs received 20 ml/kg, and 2 received 25 ml/kg; 2 dogs received PFOB, 20 ml/kg, and 2 dogs received 25 ml/kg. Just before and 2 days after PFC administration, real-time, 2-dimensional ultrasound examination of the heart was performed in the short-axis view from apex to base. No enhancement was seen at the 10-ml/kg dose, but significant mild echogenic enhancement of all MIs occurred after 20 ml/kg. Moderate to marked enhancement was noted after 25 ml/kg. The enhancement was either diffuse throughout the Ml or localized to the rim. Initial studies suggest that the mechanism of enhancement is related, at least in part, to the accumulation of RFC-filled macrophages within the MI.
UR - http://www.scopus.com/inward/record.url?scp=0021255632&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021255632&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(84)90330-8
DO - 10.1016/0002-9149(84)90330-8
M3 - Article
C2 - 6741815
AN - SCOPUS:0021255632
SN - 0002-9149
VL - 54
SP - 206
EP - 210
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 1
ER -