Ultrasound imaging of whole tumor response to drug therapy

Kenneth Hoyt, Anna G. Sorace, Reshu Saini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Use of volumetric contrast-enhanced ultrasound (US) imaging of cancer-bearing mice allows description of whole tumor perfusion and monitoring response to drug treatment. Thirty mice were implanted with breast cancer cells. Following sufficient tumor growth, mice were sorted into four treatment groups: Abraxane, TRA-8, Abraxane + TRA-8, or control. Mice were administered drug treatment on days 0, 3, 7, 10, 14, and 17. Whole tumor contrast-enhanced US imaging was performed on days 0, 1, 3, and 7 before drug dosing. At termination, tumors were excised and immunohistologic analyses were performed. Therapeutic efficacy was detected within 7 days after drug dosing with volumetric contrast-enhanced US imaging. The most significant reduction in tumor perfusion as compared to control mice measurements was observed in the TRA-8 + Abraxane dosed animals (P = 0.001). The reduction in perfusion observed in the TRA-8 + Abraxane group coincided with a reduction in tumor size during the same time period. Survival curves illustrate that combination TRA-8 + Abraxane improves drug efficacy compared to monotherapy. Overall, preliminary results demonstrate that volumetric contrast-enhanced US imaging of changes in whole tumor perfusion levels allows early monitoring of cancer response to drug therapy.

Original languageEnglish (US)
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages651-654
Number of pages4
DOIs
Publication statusPublished - Dec 1 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

    Fingerprint

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Hoyt, K., Sorace, A. G., & Saini, R. (2012). Ultrasound imaging of whole tumor response to drug therapy. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 651-654). [6562196] https://doi.org/10.1109/ULTSYM.2012.0162