Ultrasound-modulated optical tomography in reflection mode with ring-shaped light illumination

Chulhong Kim, Kwang Hyun Song, Konstantin Maslov, Lihong V. Wang

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We have succeeded in implementing ring-shaped light illumination ultrasound-modulated optical tomography (UOT) in reflection mode. The system used intense acoustic bursts and a chargecoupled device (CCD) camera-based speckle contrast detection method. In addition, the implementation allows placing the tissue sample below (not within) an acoustic coupling water tank and scanning the tissue without moving the sample. Thus, the UOT system is more clinically applicable than previous transmission-mode systems. Furthermore, we have successfully imaged an ex vivo methyleneblue-dyed sentinel lymph node (SLN) embedded at a depth of 13 mm in chicken breast tissue. This UOT system offers several advantages: noninvasiveness, nonionizing radiation, portability, cost effectiveness, and the possibility of combination with ultrasound pulse-echo imaging and photoacoustic imaging. One potential application of the UOT system is mapping SLNs in axillary staging for breast cancer patients.

Original languageEnglish (US)
Article number024015
JournalJournal of biomedical optics
Volume14
Issue number2
DOIs
StatePublished - Mar 18 2009

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Keywords

  • Axillary lymph node dissection
  • Breast cancer
  • Reflection-mode ultrasound-modulated optical tomography (UOT)
  • Ring-shaped light illumination
  • Sentinel lymph node (SLN) biopsy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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